Tocris批发，产品货源 Tocris Bioscience一级代理,Tocris/SU 11274/4101/10/10 mg,激酶,Tocris,Bio-Techne,,10 mg蚂蚁淘商城

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Tocris/SU 11274/4101/10/10 mg

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4101/10

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Description:SelectiveinhibitorofMETkinaseactivity

ChemicalName:(3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveinhibitorofMETtyrosinekinaseactivity(IC₅₀=0.01μMinvitro).Reducescellgrowthinadose-dependentmanner;inducescellcyclearrestandapoptosis.Abrogatescellmotilityandmigrationinvitroandtumorangiogenesisinvivo.

CompoundLibraries

SU11274isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	568.09
Formula	C₂₈H₃₀ClN₅O₄S
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	658084-23-2
PubChemID	9549297
InChIKey	FPYJSJDOHRDAMT-KQWNVCNZSA-N
Smiles	CC1=C(C=C(C3=CC(S(N(C)C5=CC(Cl)=CC=C5)(=O)=O)=CC=C3N4)/C4=O)NC(C)=C1C(N2CCN(C)CC2)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	28.4	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight568.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.76mL	8.8mL	17.6mL
5mM	0.35mL	1.76mL	3.52mL
10mM	0.18mL	0.88mL	1.76mL
50mM	0.04mL	0.18mL	0.35mL

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