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Tocris/SU 11274/4101/50/50 mg
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Tocris/SU 11274/4101/50/50 mg
品牌 / 
Tocris
货号 / 
4101/50
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4000-520-616
Description:SelectiveinhibitorofMETkinaseactivity
ChemicalName:(3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveinhibitorofMETtyrosinekinaseactivity(IC50=0.01μMinvitro).Reducescellgrowthinadose-dependentmanner;inducescellcyclearrestandapoptosis.Abrogatescellmotilityandmigrationinvitroandtumorangiogenesisinvivo.

CompoundLibraries

SU11274isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt568.09
FormulaC28H30ClN5O4S
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber658084-23-2
PubChemID9549297
InChIKeyFPYJSJDOHRDAMT-KQWNVCNZSA-N
SmilesCC1=C(C=C(C3=CC(S(N(C)C5=CC(Cl)=CC=C5)(=O)=O)=CC=C3N4)/C4=O)NC(C)=C1C(N2CCN(C)CC2)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO28.450

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight568.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.76mL8.8mL17.6mL
5mM0.35mL1.76mL3.52mL
10mM0.18mL0.88mL1.76mL
50mM0.04mL0.18mL0.35mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet