BiologicalActivity
Potentandselectiveplatelet-derivedgrowthfactorreceptorβ(PDGFRβ)inhibitor(IC50=10nM)thatdisplays>14-fold,>229-foldand>10000-foldselectivityoverVEGFR2,FGFR1andEGFRrespectively.InhibitsproliferationofHUVECandNIH3T3cellsinvitro(IC50=0.11μM).
CompoundLibraries
SU16fisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 386.44 |
| Formula | C24H22N2O3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 251356-45-3 |
| PubChemID | 5329150 |
| InChIKey | APYYTEJNOZQZNA-MOSHPQCFSA-N |
| Smiles | O=C2NC1=CC(C4=CC=CC=C4)=CC=C1/C2=C/C3=C(C)C(CCC(O)=O)=C(C)N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight386.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.59mL | 12.94mL | 25.88mL |
| 5mM | 0.52mL | 2.59mL | 5.18mL |
| 10mM | 0.26mL | 1.29mL | 2.59mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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