BiologicalActivity
Potentandselectivevascularendothelialgrowthfactorreceptor(VEGFR)andfibroblastgrowthfactorreceptor(FGFR)inhibitor(IC50valuesare0.02,0.03,0.51and>100μMatVEGFR2,FGFR1,PDGFRβandEGFRrespectively).Inhibitsembryonicleft-rightdeterminationandexhibitspotentanticanceractivityinvitroandinvivo.Alsoattenuatesintegrinβ4-induceddifferentiationofneuralstemcells.
TechnicalData
| M.Wt | 296.32 |
| Formula | C17H16N2O3 |
| Storage | Storeat-20°C |
| Purity | ≥95%(HPLC) |
| CASNumber | 215543-92-3 |
| PubChemID | 5289418 |
| InChIKey | JNDVEAXZWJIOKB-JYRVWZFOSA-N |
| Smiles | CC1=CNC(C=C(C2=CC=CC=C2N3)/C3=O)=C1CCC(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight296.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.37mL | 16.87mL | 33.75mL |
| 5mM | 0.67mL | 3.37mL | 6.75mL |
| 10mM | 0.34mL | 1.69mL | 3.37mL |
| 50mM | 0.07mL | 0.34mL | 0.67mL |
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