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Description:VEGFRinhibitor.AlsoinhibitsKIT,RET,METandFLT3
AlternativeNames:Semaxinib
ChemicalName:3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitorofvascularendothelialgrowthfactorreceptor(VEGFR)thatalsoinhibitsothertyrosinekinasesKIT,MET,FLT3andRET.DisplaysnoactivityagainstEGFR,HER2,IGF1RandPDGFR.Inhibitstumorvascularizationandgrowthofmultipletumortypes.
CompoundLibraries
SU5416isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 238.28 |
Formula | C15H14N2O |
Storage | Desiccateat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 204005-46-9 |
PubChemID | 5329098 |
InChIKey | WUWDLXZGHZSWQZ-WQLSENKSSA-N |
Smiles | O=C2NC1=CC=CC=C1/C2=C/C3=C(C)C=C(C)N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 23.83 | 100 | |
ethanol | 2.38 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight238.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.2mL | 20.98mL | 41.97mL |
5mM | 0.84mL | 4.2mL | 8.39mL |
10mM | 0.42mL | 2.1mL | 4.2mL |
50mM | 0.08mL | 0.42mL | 0.84mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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