BiologicalActivity
ATP-competitivePDGFR,VEGFandFGFRinhibitor(IC50valuesare0.06,2.43,3.04and>100μMatPDGFRβ,VEGFR2,FGFR1andEGFRrespectively).InhibitsproliferationofHUVECandNIH3T3cellsinvitro(IC50valuesare0.41,9.3and16.5μMforVEGF,FGFandPDGF-stimulatedgrowthrespectively)andinduces>75%growthinhibitionagainstabroadrangeoftumortypesinvivo.Exhibitsantiangiogenic,anti-inflammatory,antimetastaticandproapoptoticactivityandisorallyactive.
CompoundLibraries
SU6668isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 310.35 |
| Formula | C18H18N2O3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 252916-29-3 |
| PubChemID | 5329099 |
| InChIKey | NHFDRBXTEDBWCZ-ZROIWOOFSA-N |
| Smiles | O=C2NC1=CC=CC=C1/C2=C/C3=C(C)C(CCC(O)=O)=C(C)N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 31.03 | 100 | |
| DMSO | 31.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight310.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.22mL | 16.11mL | 32.22mL |
| 5mM | 0.64mL | 3.22mL | 6.44mL |
| 10mM | 0.32mL | 1.61mL | 3.22mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |
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