Tocris美元价/进货价 Tocris配体,Tocris/Sunitinib malate/3768/10/10 mg,激酶,Tocris,Bio-Techne,,10 mg蚂蚁淘商城

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Tocris/Sunitinib malate/3768/10/10 mg

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Tocris

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3768/10

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4000-520-616

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Description:PotentVEGFR,PDGFRβandKITinhibitor

AlternativeNames:SU11248

ChemicalName:N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide(2S)-2-hydroxybutanedioatesalt

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,ATP-competitiveVEGFR,PDGFRβandKITinhibitor(K_ivaluesare2,9,17,8and4nMforVEGFR-1,-2,-3,PDGFRβandKITrespectively).AlsoinhibitscellularreceptorphosphorylationofFLT3,RETandCSF-1R.Exhibitsantiangiogenicandantitumoractivityinmultiplexenograftmodels.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

SunitinibmalateisalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	532.56
Formula	C₂₂H₂₇FN₄O₂.C₄H₆O₅
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	341031-54-7
PubChemID	6456015
InChIKey	LBWFXVZLPYTWQI-IPOVEDGCSA-N
Smiles	O=C(NCCN(CC)CC)C1=C(C)NC(/C=C2C(NC3=C2C=C(F)C=C3)=O)=C1C.OC(C[C@H](O)C(O)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	13.31	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight532.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.88mL	9.39mL	18.78mL
5mM	0.38mL	1.88mL	3.76mL
10mM	0.19mL	0.94mL	1.88mL
50mM	0.04mL	0.19mL	0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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