BiologicalActivity
PotentinhibitorofFLT3receptortyrosinekinase(IC50=42nM)thatdisplaysselectivityoverarangeofotherkinases.ExhibitsantiproliferativeeffectsonMV4-11cells,ahumanacutemyelogenousleukemiacelllineexpressingaconstitutivelyactivemutantFLT3(IC50=340nM).
CompoundLibraries
TCS359isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 360.43 |
| Formula | C18H20N2O4S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 301305-73-7 |
| PubChemID | 1048845 |
| InChIKey | FSPQCTGGIANIJZ-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1OC)C(=O)NC1=C(C(N)=O)C2=C(CCCC2)S1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.81 | 30 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight360.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.87mL | 27.74mL |
| 5mM | 0.55mL | 2.77mL | 5.55mL |
| 10mM | 0.28mL | 1.39mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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