BiologicalActivity
PotentirreversiblepanErbBinhibitor(IC50valuesare6.0,45.7and73.7nMforEGFR,ERBB2andERBB4,respectively).InhibitsmutantandwildtypeformsofErbB,includingEGFRT780M,andshowsactivityinNSCLCcelllinessensitiveandresistanttoIressa(Cat.No.3000).Inhibitstumorgrowth.Orallybioavailable.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 469.94 |
| Formula | C24H25ClFN5O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1110813-31-4 |
| PubChemID | 11511120 |
| InChIKey | LVXJQMNHJWSHET-AATRIKPKSA-N |
| Smiles | O=C(/C=C/CN1CCCCC1)NC2=C(OC)C=C(N=CN=C3NC4=CC=C(F)C(Cl)=C4)C3=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 46.99 | 100 | |
| DMSO | 46.99 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight469.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.13mL | 10.64mL | 21.28mL |
| 5mM | 0.43mL | 2.13mL | 4.26mL |
| 10mM | 0.21mL | 1.06mL | 2.13mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。