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Description:InhibitorofVEGFreceptortyrosinekinase
ChemicalName:4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazolinehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitorofvascularendothelialgrowthfactor(VEGF)receptortyrosinekinase.InhibitsactivityofKDRandFLTVEGFreceptors(IC50valuesare100nMand2μMrespectively)anddisplays>3-foldselectivityoverFGFR-1.Orallyactiveinvivo.
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
TechnicalData
M.Wt | 370.21 |
Formula | C16H13N3O2FCl.HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 196603-47-1 |
PubChemID | 21701577 |
InChIKey | SCUXIROMWPQVJO-UHFFFAOYSA-N |
Smiles | Cl.COC1=C(OC)C=C2C(NC3=CC=C(Cl)C=C3F)=NC=NC2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.7 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight370.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.7mL | 13.51mL | 27.01mL |
5mM | 0.54mL | 2.7mL | 5.4mL |
10mM | 0.27mL | 1.35mL | 2.7mL |
50mM | 0.05mL | 0.27mL | 0.54mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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