Tocris试剂采购 Tocris抗体,Tocris/AG 1478 hydrochloride/1276/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AG 1478 hydrochloride/1276/50/50 mg

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Tocris/AG 1478 hydrochloride/1276/50/50 mg

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Tocris

货号 /

1276/50

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4000-520-616

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Description:HighlypotentEGFR-kinaseinhibitor

AlternativeNames:TyrphostinAG1478

ChemicalName:N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinaninehydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectiveinhibitorofepidermalgrowthfactorreceptorkinase(IC₅₀values3nMforEGFRand>100μMforErbB2andPDGFR).InhibitsproliferationofNCI-H2170NSCLCcellsinvitro(IC₅₀=1μM).

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

TechnicalData

M.Wt	352.22
Formula	C₁₆H₁₄ClN₃O₂.HCl
Storage	Desiccateat-20°C
Purity	≥98%(HPLC)
CASNumber	170449-18-0
PubChemID	3035187
InChIKey	WDJDYIUSDDVWKB-UHFFFAOYSA-N
Smiles	ClC1=CC(NC2=NC=NC3=C2C=C(OC)C(OC)=C3)=CC=C1.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	3.52	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight352.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.84mL	14.2mL	28.39mL
5mM	0.57mL	2.84mL	5.68mL
10mM	0.28mL	1.42mL	2.84mL
50mM	0.06mL	0.28mL	0.57mL

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