BiologicalActivity
Inhibitorofepidermalgrowthfactorreceptor(EGFR)andplatelet-derivedgrowthfactorreceptor(PDGFR)kinase(IC50valuesare35and25μMrespectively).InhibitsEGF-stimulatedcellproliferation.Alsoactsasamitochondrialuncouplerthataltersphosphorylation-dependentcellsignaling.
TechnicalData
| M.Wt | 186.17 |
| Formula | C10H6N2O2 |
| Storage | Desiccateat+4°C |
| CASNumber | 118409-57-7 |
| PubChemID | 2052 |
| InChIKey | VTJXFTPMFYAJJU-UHFFFAOYSA-N |
| Smiles | OC1=C(O)C=C(C=C(/C#N)C#N)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.62 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight186.17.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.37mL | 26.86mL | 53.71mL |
| 5mM | 1.07mL | 5.37mL | 10.74mL |
| 10mM | 0.54mL | 2.69mL | 5.37mL |
| 50mM | 0.11mL | 0.54mL | 1.07mL |
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