BiologicalActivity
SelectiveinhibitorofEGFreceptortyrosinekinase(IC50valuesare2and13.5μMforEGFRandErbB2respectively).InhibitorofJAK2,JAK3/STAT,JAK3/AP-1andJAK3/MAPKpathwaysandpotentlyinhibitscytokine-independentcellgrowthinvitroandtumorcellinvasioninvivo.
TechnicalData
| M.Wt | 294.31 |
| Formula | C17H14N2O3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 133550-30-8 |
| PubChemID | 5328779 |
| InChIKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| Smiles | OC1=C(O)C=C(C=C(/C#N)C(=O)NCC2=CC=CC=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.43 | 100 | |
| ethanol | 5.89 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight294.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.4mL | 16.99mL | 33.98mL |
| 5mM | 0.68mL | 3.4mL | 6.8mL |
| 10mM | 0.34mL | 1.7mL | 3.4mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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