进口Tocris品牌清关代理 Tocris BioscienceX中国代理价格，厂家,Tocris/AG 490/0414/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AG 490/0414/50/50 mg

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Tocris

货号 /

0414/50

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4000-520-616

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Description:EGFR-kinaseinhibitor.AlsoJAK2,JAK3inhibitor

AlternativeNames:TyrphostinAG490

ChemicalName:(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveinhibitorofEGFreceptortyrosinekinase(IC₅₀valuesare2and13.5μMforEGFRandErbB2respectively).InhibitorofJAK2,JAK3/STAT,JAK3/AP-1andJAK3/MAPKpathwaysandpotentlyinhibitscytokine-independentcellgrowthinvitroandtumorcellinvasioninvivo.

TechnicalData

M.Wt	294.31
Formula	C₁₇H₁₄N₂O₃
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	133550-30-8
PubChemID	5328779
InChIKey	TUCIOBMMDDOEMM-RIYZIHGNSA-N
Smiles	OC1=C(O)C=C(C=C(/C#N)C(=O)NCC2=CC=CC=C2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	29.43	100
	ethanol	5.89	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight294.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.4mL	16.99mL	33.98mL
5mM	0.68mL	3.4mL	6.8mL
10mM	0.34mL	1.7mL	3.4mL
50mM	0.07mL	0.34mL	0.68mL

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PreparingStockSolutions

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