Tocris配体 TOCRIS 4372-10MG,Tocris/AG 494/0619/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AG 494/0619/10/10 mg

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Tocris

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0619/10

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4000-520-616

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Description:PotentEGFR-kinaseinhibitor

ChemicalName:(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofepidermalgrowthfactorreceptor(EGFR)kinase(IC₅₀=0.7μM).SelectiveoverErbB2,PDGFRandinsulinreceptorkinase(IC₅₀valuesare42,6and>100μMrespectively).

TechnicalData

M.Wt	280.28
Formula	C₁₆H₁₂N₂O₃
Storage	Desiccateat+4°C
CASNumber	133550-35-3
PubChemID	5328771
InChIKey	HKHOVJYOELRGMV-XYOKQWHBSA-N
Smiles	OC1=C(O)C=C(C=C(/C#N)C(=O)NC2=CC=CC=C2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	14.01	50
	ethanol	1.4	5

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight280.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.57mL	17.84mL	35.68mL
5mM	0.71mL	3.57mL	7.14mL
10mM	0.36mL	1.78mL	3.57mL
50mM	0.07mL	0.36mL	0.71mL

ProductDatasheets

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BiologicalActivity

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SolubilityData

PreparingStockSolutions

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