BiologicalActivity
Potentepidermalgrowthfactorreceptor(EGFR)kinaseinhibitor(IC50=0.7μM)thatdisplays50-foldand>140-foldselectivityoverErbB2andinsulinreceptorkinaserespectively.InduceG1growtharrestselectivelyintransformedcells(IC50valuesare6.4and9.4μMinHPV16-immortalizedandnormalkeratinocytesrespectively).
TechnicalData
| M.Wt | 322.36 |
| Formula | C19H18N2O3 |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 133550-34-2 |
| PubChemID | 5328770 |
| InChIKey | GSQOBTOAOGXIFL-LFIBNONCSA-N |
| Smiles | OC1=CC=C(C=C(/C#N)C(=O)NCCCC2=CC=CC=C2)C=C1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.67 | 30 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight322.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.1mL | 15.51mL | 31.02mL |
| 5mM | 0.62mL | 3.1mL | 6.2mL |
| 10mM | 0.31mL | 1.55mL | 3.1mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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