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Description:EGFR-kinaseinhibitor
AlternativeNames:TyrphostinAG556
ChemicalName:(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Epidermalgrowthfactorreceptor(EGFR)kinaseinhibitor(IC50=1.1μM).SelectiveoverErbB2(IC50>500μM).
TechnicalData
| M.Wt | 336.39 |
| Formula | C20H20N2O3 |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 133550-41-1 |
| PubChemID | 5328775 |
| InChIKey | GWCNJMUSWLTSCW-SFQUDFHCSA-N |
| Smiles | OC1=C(O)C=C(C=C(/C#N)C(=O)NCCCCC2=CC=CC=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.09 | 30 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight336.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.97mL | 14.86mL | 29.73mL |
| 5mM | 0.59mL | 2.97mL | 5.95mL |
| 10mM | 0.3mL | 1.49mL | 2.97mL |
| 50mM | 0.06mL | 0.3mL | 0.59mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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