BiologicalActivity
Epidermalgrowthfactorreceptor(EGFR)kinaseinhibitor(IC50=10μM)thatisselectiveoverinsulinreceptorkinase.Blockstyrosinephosphorylationofp145metandpromotescelldeathofnormalandcancercellsviaactivationofcaspase-likeproteasesinvitro.
TechnicalData
| M.Wt | 204.18 |
| Formula | C10H8N2O3 |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 122520-85-8 |
| PubChemID | 5328768 |
| InChIKey | USOXQZNJFMKTKJ-XVNBXDOJSA-N |
| Smiles | NC(=O)C(=CC1=CC(O)=C(O)C=C1)C#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.42 | 100 | |
| ethanol | 1.02 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight204.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.9mL | 24.49mL | 48.98mL |
| 5mM | 0.98mL | 4.9mL | 9.8mL |
| 10mM | 0.49mL | 2.45mL | 4.9mL |
| 50mM | 0.1mL | 0.49mL | 0.98mL |
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