BiologicalActivity
TrkBreceptorantagonist.Demonstratesa2-sitemodeofaction,preventingactivationbyBDNFnon-competitively(IC50valuesare45.6nMand41.1μMforthehighandlowaffinitysitesrespectively).DisplaysnoeffectonTrkAandTrkCinanassayofneuriteoutgrowth.Demonstratesantidepressantproperties.
CompoundLibraries
ANA12isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 407.49 |
| Formula | C22H21N3O3S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 219766-25-3 |
| PubChemID | 2799722 |
| InChIKey | TUSCYCAIGRVBMD-UHFFFAOYSA-N |
| Smiles | O=C(NC4C(NCCCC4)=O)C1=C(NC(C2=CC3=C(C=CC=C3)S2)=O)C=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.37 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight407.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.45mL | 12.27mL | 24.54mL |
| 5mM | 0.49mL | 2.45mL | 4.91mL |
| 10mM | 0.25mL | 1.23mL | 2.45mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |
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