Tocris型号参数规格 TOCRIS 4372-10MG,Tocris/ASP 3026/5310/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/ASP 3026/5310/10/10 mg

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Tocris

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5310/10

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4000-520-616

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Description:Potentanaplasticlymphomakinase(ALK)inhibitor;alsopotentACKinhibitor

ChemicalName:N²-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentanaplasticlymphomakinase(ALK)inhibitor(IC₅₀=3.5nM).AlsoinhibitsAckandROS1activity(IC₅₀valuesare5.8and8.9nMrespectively).Attenuatesproliferation,andinducesapoptosisofNPM-ALK⁺Tcellanaplasticlarge-celllymphoma(ALCL)cellsinvitro.SuppressestumorgrowthofNPM-ALK⁺ALCLcellxenograftsinmice.CausestumorshrinkageinhEML4-ALKtransgenicmice.Orallyavailable.

CompoundLibraries

ASP3026isalsoofferedaspartoftheTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	580.74
Formula	C₂₉H₄₀N₈O₃S
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	1097917-15-1
PubChemID	25134326
InChIKey	MGGBYMDAPCCKCT-UHFFFAOYSA-N
Smiles	CN1CCN(C2CCN(C3=CC=C(NC4=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=NC=N4)C(OC)=C3)CC2)CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	11.61	20
	ethanol	2.9	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight580.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.72mL	8.61mL	17.22mL
5mM	0.34mL	1.72mL	3.44mL
10mM	0.17mL	0.86mL	1.72mL
50mM	0.03mL	0.17mL	0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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