Tocris公司代理生物计划 Tocris抗体,Tocris/ASP 3026/5310/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

商品信息

联系客服

郑重提醒：

无质量问题不接受退换货，下单前请仔细核对信息。

下单后请及时联系客服核对商品价格，订单生效后再付款。

Tocris/ASP 3026/5310/50/50 mg

品牌 /

Tocris

货号 /

5310/50

官网地址

美元价：

登录查看

(友情提示：该价格仅为参考，欢迎联系客服询价！)

数量：

免费咨询热线

4000-520-616

商品介绍售后保障相关文章商品咨询

联系客服

Description:Potentanaplasticlymphomakinase(ALK)inhibitor;alsopotentACKinhibitor

ChemicalName:N²-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentanaplasticlymphomakinase(ALK)inhibitor(IC₅₀=3.5nM).AlsoinhibitsAckandROS1activity(IC₅₀valuesare5.8and8.9nMrespectively).Attenuatesproliferation,andinducesapoptosisofNPM-ALK⁺Tcellanaplasticlarge-celllymphoma(ALCL)cellsinvitro.SuppressestumorgrowthofNPM-ALK⁺ALCLcellxenograftsinmice.CausestumorshrinkageinhEML4-ALKtransgenicmice.Orallyavailable.

CompoundLibraries

ASP3026isalsoofferedaspartoftheTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	580.74
Formula	C₂₉H₄₀N₈O₃S
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	1097917-15-1
PubChemID	25134326
InChIKey	MGGBYMDAPCCKCT-UHFFFAOYSA-N
Smiles	CN1CCN(C2CCN(C3=CC=C(NC4=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=NC=N4)C(OC)=C3)CC2)CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	11.61	20
	ethanol	2.9	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight580.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.72mL	8.61mL	17.22mL
5mM	0.34mL	1.72mL	3.44mL
10mM	0.17mL	0.86mL	1.72mL
50mM	0.03mL	0.17mL	0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

Selectanotherlanguage:

BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets