880228 | DSPE-PEG(2000) Azide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt)

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Info

DSPE-PEG(2000) Azide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt)

Cu-free click chemistry with readily synthesized biarylazacyclooctynones. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole product without the need for a toxic catalyst.

Also, refer to DSPE-PEG DBCO Avanti Number 880229

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG.

Data

Hygroscopic

Yes

Light Sensitive

No

Molecular Formula

C₁₃₂H₂₆₄N₅O₅₄P (average MW due to polydispersity of PEG)

Percent Composition

C 56.29%, H 9.45%, N 2.49%, O 30.67%, P 1.10%

Purity

>99%

Stability

1 Year

Storage Temperature

-20°C

CAS Number

1938081-40-3 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

2816.519

Exact Mass

2814.78

Synonyms

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-azido(polyethylene glycol)-2000] (ammonium salt)

Downloads

• ChemDraw File
• 3D Structure
• Structure
• Safety Data Sheet
• Safety Data Sheet

References

Xiao Y, Liu Q, Clulow AJ, Li T, Manohar M, Gilbert EP, de Campo L, Hawley A, Boyd BJ. PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery. Colloids Surf B Biointerfaces. 2019 Jul 15;182:110362. doi: 10.1016/j.colsurfb.2019.110362. [Epub ahead of print]

PubMed ID: 31351271

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Girish A, Hickman DA, Banerjee A, Luc N, Ma Y, Miyazawa K, Sekhon UDS, Sun M, Huang S, Sen Gupta A. Trauma-targeted delivery of tranexamic acid improves hemostasis and survival in rat liver hemorrhage model. J Thromb Haemost. 2019 Jun 20. doi: 10.1111/jth.14552. [Epub ahead of print]

PubMed ID: 31220416

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Paek J, Park SE, Lu Q, Park KT, Cho M, Oh JM, Kwon KW, Yi YS, Song JW, Edelstein HI, Ishibashi J, Yang W, Myerson JW, Kiseleva RY, Aprelev P, Hood ED, Stambolian D, Seale P, Muzykantov VR, Huh D. Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues. ACS Nano. 2019 Jun 18. doi: 10.1021/acsnano.9b00686. [Epub ahead of print]

PubMed ID: 31194909

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Hood ED, Greineder CF, Shuvaeva T, Walsh L, Villa CH, Muzykantov VR. Vascular targeting of radiolabeled liposomes with bio-orthogonally conjugated ligands: single chain fragments provide higher specificity than antibodies. Bioconjug Chem. 2018 Sep 21. doi: 10.1021/acs.bioconjchem.8b00564. [Epub ahead of print]

PubMed ID: 30240185

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Jewett, J.C., E.M. Sletten, and C.R. Bertozzi. (2010). Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc 132:3688-90.

PubMed ID: 20187640

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Certificates of Analysis

• Certificate of Analysis(Lot No. 880228C-10MG-A-012and 6307CIA012)
• Certificate of Analysis(Lot No. 880228P-100MG-A-012and 6307PLA012)
• Certificate of Analysis(Lot No. 880228P-10MG-A-012and 6307PIA012)
• Certificate of Analysis(Lot No. 880228P-25MG-A-012and 6307PJA012)
• Certificate of Analysis(Lot No. 880228P-500MG-A-012and 6307PPA012)
• Certificate of Analysis(Lot No. 880228P-50MG-A-012and 6307PKA012)
• Certificate of Analysis(Lot No. 880228P-50MG-A-013and 6307PKA01)
• Certificate of Analysis(Lot No. 880228P-100MG-A-013and 6307PLA013)
• Certificate of Analysis(Lot No. 880228P-25MG-A-013-6307PJA013and 6307PJA013)
• Certificate of Analysis(Lot No. 880228P-50MG-B-013and 6307PKB013)
• Certificate of Analysis(Lot No. 880228P-10MG-B-013and 6307PIB013)
• Certificate of Analysis(Lot No. 880228P-10MG-C-013and 6307PIC013)
• Certificate of Analysis(Lot No. 880228C-10MG-A-013and 6307CIA013)
• Certificate of Analysis(Lot No. 880228P-100MG-B-013and 6307PLB013)
• Certificate of Analysis(Lot No. 880228C-10MG-B-013and 6307CIB013)
• Certificate of Analysis(Lot No. 880228P-50MG-C-013and 6307PKC013)
• Certificate of Analysis(Lot No. 880228P-25MG-B-012and 6307PJB012)
• Certificate of Analysis(Lot No. 880228P-100MG-B-012and 6307PLB012)
• Certificate of Analysis(Lot No. 880228P-100MG-D-012and 6307PLD012)
• Certificate of Analysis(Lot No. 880228P-25MG-B-013and 6307PJB013)
• Certificate of Analysis(Lot No. 880228P-100MG-C-013and 6307PLC013)
• Certificate of Analysis(Lot No. 880228P-50MG-D-013and 6307PKD013)
• Certificate of Analysis(Lot No. 880228P-10MG-A-013and 6307PIA013)
• Certificate of Analysis(Lot No. 880228P-25MG-C-013and 6307PJC013)
• Certificate of Analysis(Lot No. 880228P-100MG-D-013and 6307PLD013)
• Certificate of Analysis(Lot No. 880228P-50MG-E-013and 6307PKE013)
• Certificate of Analysis(Lot No. 880228P-10MG-D-013and 6307PID013)
• Certificate of Analysis(Lot No. 880228P-50MG-F-013and 6307PKF013)
• Certificate of Analysis(Lot No. 880228P-50MG-G-013and 6307PKG013)
• Certificate of Analysis(Lot No. 880228P-25MG-D-013and 6307PJD013)
• Certificate of Analysis(Lot No. 880228P-100MG-E-013and 6307PLE013)
• Certificate of Analysis(Lot No. 880228P-100MG-F-013and 6307PLF013)
• Certificate of Analysis(Lot No. 880228P-10MG-F-013and 6307PIF013)
• Certificate of Analysis(Lot No. 880228P-25MG-A-014and 6307PJA014)
• Certificate of Analysis(Lot No. 880228P-50MG-A-014and 6307PKA014)
• Certificate of Analysis(Lot No. 880228C-10MG-A-014and 6307CIA014)
• Certificate of Analysis(Lot No. 880228P-100MG-A-014and 6307PLA014)
• Certificate of Analysis(Lot No. 880228P-100MG-B-014and 6307PLB014)
• Certificate of Analysis(Lot No. 880228P-50MG-B-014and 6307PKB014)

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