Oligo Synthesis : CEPs
Prices quoted are for single packs only. For multiples of the same product please request a quote. Some of Glen"sproductsarehazardousandmay be subject to additional shipping charges. Full product information is available onGlen Research"s website.
GalNAc C3 Phosphoramidite
Deprotection: As required by nucleobases. Compatible with 30% ammonium hydroxide for 2 hours at 65°C, 17 hours at room temperature, AMA (ammonium hydroxide/40% methylamine 1:1) for 10 minutes at 65 °C and UltraMild deprotection conditions. Note extended deprotection in ammonium hydroxide (17 hours at 55 °C) will lead to some degradation.
Glen Research
| Catalogue No. | Description | Pack Size | Price | Qty |
|
|---|---|---|---|---|---|
| 10-1974-02 | GalNAc C3 Phosphoramidite | 0.25g | £400.00£380.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-1974-90 | GalNAc C3 Phosphoramidite | 100µmoles | £204.00£193.80Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 10-1974-95 | GalNAc C3 Phosphoramidite | 50µmoles | £110.00£104.50Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 20-2974-01 | GalNAc C3 CPG | 0.1g | £50.00£47.50Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 20-2974-10 | GalNAc C3 CPG | 1.0g | £256.00£243.20Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 20-2974-13 | GalNAc C3 CPG | 1x10 µmole | £144.00£136.80Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 20-2974-14 | GalNAc C3 CPG | 1x 15 µmole | £224.00£212.80Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 20-2974-41 | GalNAc C3 CPG | 4x 1.0 µmoles | £80.00£76.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
| 20-2974-42 | GalNAc C3 CPG | 4x0.2 µmole | £60.00£57.00Offer until : 31-Mar-2021Offer Code : GLEN5View Offer | Quantity | Add to Order |
GalNAc C3 Phosphoramidite
Deprotection: As required by nucleobases. Compatible with 30% ammonium hydroxide for 2 hours at 65°C, 17 hours at room temperature, AMA (ammonium hydroxide/40% methylamine 1:1) for 10 minutes at 65 °C and UltraMild deprotection conditions. Note extended deprotection in ammonium hydroxide (17 hours at 55 °C) will lead to some degradation.
Glen Research
N-Acetylgalactosamine (GalNAc) Oligonucleotide Conjugates
A directed approach to the delivery of therapeutic oligonucleotides specifically to the liver has been to target the asialoglycoprotein receptor (ASGPR) using a suitable glycoconjugate. Indeed, ASGPR is the ideal target for delivery of therapeutic oligonucleotides to the liver since it combines tissue specificity, high expression levels and rapid internalization and turnover. The use of oligonucleotide glycoconjugates has led to significant advances in therapeutic delivery as evidenced by the work of Alnylam Pharmaceuticals and Ionis Pharmaceuticals using multivalent N-acetylgalactosamine (GalNAc) oligonucleotide conjugates.Glen Research is delighted to introduce a GalNAc modification strategy using a monomeric GalNAc support and the equivalent GalNAc phosphoramidite. Our experimental work has shown that these products are fully compatible with regular oligonucleotide synthesis and deprotection. Oligonucleotides containing GalNAc can be deprotected using standard procedures during which the acetyl protecting groups on the GalNAc group are removed. We have demonstrated that 5"-GalNAc C3 phosphoramidite can be used to prepare oligonucleotides with multiple consecutive GalNAc additions at the 5" terminus.Glen Research offers these GalNAc C3 products under an agreement with AM Chemicals LLC.
Diluent: Anhydrous Acetonitrile
Coupling: 12 minute coupling time is recommended.
Deprotection: As required by nucleobases. Compatible with 30% ammonium hydroxide for 2 hours at 65°C, 17 hours at room temperature, AMA (ammonium hydroxide/40% methylamine 1:1) for 10 minutes at 65 °C and UltraMild deprotection conditions. Note extended deprotection in ammonium hydroxide (17 hours at 55 °C) will lead to some degradation.
Storage: Refrigerated storage, maximum of 2-8°C, dry
Stability in Solution: 1-2 Days
Please Note: GalNAc C3 products are sold under agreement with AM Chemicals LLC.
If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200
AthensResearch&Technology公司位于美国乔治亚州雅典市，从1986年以来一直致力于纯化高纯度，高活性的人类蛋白质和开发这些蛋白的多克隆抗血清。我们的常规产品包括丝氨酸蛋白酶、蛋白酶抑制剂、中性粒细胞酶、载脂蛋白、脂蛋白，血小板蛋白、转铁蛋白、免疫球蛋白等。二十年多年来，世界各地的研究人员都在使用我们公司的产品。在炎症、冠状动脉疾病、自身免疫性疾病、癌症、老年痴呆症等等研究的主要科学出版物中都能看到引用我们公司的产品。我们提供优质，可靠的产品和出色的客户服务。我们期待着您的业务。如果需要定制研究服务，AthensResearch&Technology公司能够根据您的项目要求提供无与伦比的试剂。
公司主要产品：一、凝血因子相关系列产品：包括多款从人血浆、血小板中分离纯化的凝血因子相关蛋白。二、酶及抑制剂系列产品：包括多款从人血浆、红细胞分离纯化的a-抗糜蛋白酶、a1/2抗胰蛋白酶、抗凝血酶、C1酯酶抑制因子、Calpain-1等酶及其抑制剂产品。三、免疫球蛋白系列产品：包括多款从人血浆、骨髓瘤、初乳以及狗和小鼠血浆中分离纯化的免疫球蛋白产品。四、脂蛋白及载脂蛋白系列产品：包括包括多款从人血浆中分离纯化的载脂蛋白及脂蛋白（高密度、中等密度、低密度、极低密度脂蛋白）产品。五、低内毒素蛋白系列产品：包括多款适宜于细胞培养的低内毒素脂蛋白、免疫球蛋白及转铁蛋白产品。六、乳蛋白系列产品：包括从人乳中分离纯化的乳白蛋白、乳铁传递蛋白及分泌型免疫球蛋白A。七、中性粒细胞源蛋白系列产品：包括多款纯化分离自人中性粒细胞的Azurocidin 、CathepsinG及Lactoferrin等蛋白产品。八、血小板相关系列产品：包括纯化分离自人血小板的血小板因子4及凝血酶致敏蛋白。九、转铁蛋白及脱铁转铁蛋白（APOTRANSFERRINS）系列产品：包括多款纯化分离自人、大小鼠、狗及食蟹猴血浆中的转铁蛋白/脱铁转铁蛋白，可应用于细胞或组织培养。十、抗体系列产品：包括多款兔、大鼠、羊源的多克隆抗体产品。
ebiomall.com
