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ProteinTech/Caspase 1/p20/p10 Polyclonal antibody/150ul/22915-1-AP

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ProteinTech/Caspase 1/p20/p10 Polyclonal antibody/150ul/22915-1-AP

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ProteinTech

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22915-1-AP

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Tested Applications

Positive WB detected in	RAW264.7, Raji cells,MCF-7 cells,NIH/3T3 cells,HeLa cells,C6 cells,Jurkat cells
Positive IHC detected in	human spleen tissueNote: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in	C6 cells

Recommended dilution

Application	Dilution
Western Blot (WB)	WB : 1:500-1:2000
Immunohistochemistry (IHC)	IHC : 1:100-1:400
Immunofluorescence (IF)	IF : 1:10-1:100
Sample-dependent, check data in validation data gallery

Published Applications

WB	See 100 publications below
IHC	See 14 publications below
IF	See 14 publications below

Product Information

The immunogen of 22915-1-AP is Caspase 1/p20/p10 Fusion Protein expressed in E. coli.

Tested Reactivity	human,mouse,rat
Cited Reactivity	cow, human, mouse, rat
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Caspase 1/p20/p10 fusion protein Ag11143
Full Name	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Calculated molecular weight	404 aa, 45 kDa
Observed molecular weight	45-47 kDa, 30 kDa, 35 kDa
GenBank accession number	BC062327
Gene symbol	CASP1
Gene ID (NCBI)	834
Conjugate	Unconjugated
Form	Liquid
Purification Method	Antigen affinity purification
Storage Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for-20^oC storage.

Background Information

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20..

Protocols

Product Specific Protocols
WB protocol for Caspase 1/p20/p10 antibody 22915-1-AP	Download protocol
IHC protocol for Caspase 1/p20/p10 antibody 22915-1-AP	Download protocol
IF protocol for Caspase 1/p20/p10 antibody 22915-1-AP	Download protocol

Standard Protocols
Click here to view our Standard Protocols

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