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BD Biosciences/PerCP Mouse Anti-Human CD8/20 μL/347314

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BD Biosciences/PerCP Mouse Anti-Human CD8/20 μL/347314

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347314

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Product DetailsRecommended AssayReferences

Description

CD8 clone SK1 is derived from hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human peripheral blood T lymphocytes.

The CD8 antibody recognizes the 32-kilodalton (kDa) α-subunit of a disulfide-linked bimolecular complex. The majority of peripheral blood CD8⁺ T lymphocytesexpress an α/β heterodimer (Mr 32, 30 kDa), while CD8⁺CD16⁺ natural killer (NK)lymphocytes and CD8⁺ T-cell receptor (TCR)-γ/δ⁺ T lymphocytes express an α/α homodimer (Mr 30 kDa). CD8⁺TCR-α/β⁺ T lymphocytes can express either an α/α homodimer or α/β heterodimer. The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules, resulting in increased adhesion between the CD8+ T lymphocytes and target cells. Binding of the CD8 antigen to class I MHC molecules enhances the activation of resting T lymphocytes. The CD8 antigen is coupled to a protein tyrosine kinase, p56^lck. The CD8:p56^lck complex can play a role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex.

Format

FormatPerCP
Excitation SourceBlue 488 nm
Excitation Max482nm
Emission Max678nm

PerCP is a component of the photosynthetic apparatus found in the dinoflagellate Glenodinium. PerCP is a protein complex with a molecular weight of approximately 35 kDa. Due to its photobleaching characteristics, PerCP conjugates are not recommended for use on flow cytometers with high-power lasers (>25 mW).

Resources & Tools
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Preparation and Storage

Store vials at 2°C to 8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

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