Pepinh-MYD
| Pepinh-MYD | Unit size | Cat. code | Docs | Price |
|---|---|---|---|---|
MyD88 inhibitory peptide | 2 mg | tlrl-pimyd | TDSMSDS | Please contact our distributor Add to favorite |
- About
- Specifications
- Contents
- Citations
MyD88 Inhibitory Peptide
Pepinh-MYD is a 26 aa peptide that blocks MyD88 signaling by inhibiting its homodimerization through binding.
Pepinh-MYD contains a sequence from the MyD88 TIR homodimerization domain (RDVLPGT) [1] preceeded by a protein transduction sequence (RQIKIWFQNRRMKWKK) derived from antennapedia which enables the peptide to translocate through the cell membrane [2].
Pepinh-MYD is provided with Pepinh-Control, a control peptide [3].
References:
1. loiarro M. et al., 2005. Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-{kappa}B. J. Biol. Chem., 280: 15809-14.2. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.3. Toshchakov V. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.
Back to the topSpecifications
Working concentration: 5-50 μM
Purity: ≥95% (UHPLC)
Species reactivity: Human, mouse
Sequences:
- Pepinh-MYD: RQIKIWFQNRRMKWKK-RDVLPGTCVNS-NH2 (MyD88 homodimerization sequence is underlined)
- Pepinh-Control: RQIKIWFQNRRMKWKK-SLHGRGDPMEAFII-NH2
Molecular weights:
- Pepinh-MYD: 3430
- Pepinh-Control: 3812
Contents
Pepinh-MYD is provided as a white solid.
- 2 mg of lyophilized Pepinh-MYD
- 2 mg of lyophilized Pepinh-Control
- 2x1.5 ml endotoxin-free water
Pepinh-MYD is shipped at room temperature.
Store at -20°C.
Solid product is stable 1 year at -20°C.
Upon resuspension, Pepinh-MYD should be aliquoted and stored at -20°C.
Avoid repeated freeze-thaw cycles.
Resuspended product is stable for 6-8 months at -20°C when properly stored.
Back to the topCitations
2019 BJC DOI: 10.1038/s41416-019-0595-2
Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.
Chen Q. et al.
2018 Microb Pathog. DOI: 10.1016/j.micpath.2018.09.037
Induction of TNF, CXCL8 and IL-1β in macrophages by Helicobacter pylori secreted protein HP1173 occurs via MAP-kinases, NF-κB and AP-1 signaling pathways.
Tavares R. & Pathak SK.
2017 Neoplasia. 19(3):175-184.
] The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression.
Singh P. et al.
2017 Biomaterials. 134:128-142.
A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis.
Feng Y. et al.
2017 Cell Tissue Res. 369(3):541-554.
CpG oligonucleotide-mediated co-stimulation of mouse invariant natural killer T cells negatively regulates their activation status.
Kulkarni RR. et al.
2017 Cardiovasc Res. 114(1):180-187.
IL-1R and MyD88 signaling in CD4+ T cells promote Th17 immunity and atherosclerosis.
Engelbertsen D. et al.
2016 J Immunol. 196(5):2085-94
LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.
Llibre A. et al.
2016 Mucosal Immunol. 10(4):924-935.
MV140, a sublingual polyvalent bacterial preparation to treat recurrent urinary tract infections, licenses human dendritic cells for generating Th1, Th17, and IL-10 responses via Syk and MyD88.
Benito-Villalvilla C. et al.
2014 Diabetes. 63(11):3815-26
Nucleotides released from palmitate challenged muscle cells through pannexin-3 attract monocytes.
Pillon NJ, Li YE, Fink LN, Brozinick JT, Nikolayev A, Kuo MS, Bilan PJ, Klip A
2013 J Biol Chem. 288(42):30544-57
Endogenous interleukin-1β in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic N-methyl-D-aspartic acid receptors.
Yan X, Weng HR.
2013 J Biol Chem. 288(15):10715-21
Interferon-{gamma} and Granulocyte/Monocyte Colony-stimulating Factor Production by Natural Killer Cells Involves Different Signaling Pathways and the Adaptor Stimulator of Interferon Genes (STING)
Souza-Fonseca-Guimaraes F, Parlato M, de Oliveira RB, Golenbock D, Fitzgerald K, Shalova IN, Biswas SK, Cavaillon JM, Adib-Conquy M.
2012 J Neurosci. 32(22):7745-7757
Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons.
Hosmane S, Tegenge MA, Rajbhandari L, Uapinyoying P, Kumar NG, Thakor N, Venkatesan A
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