EZ1 Advanced XL

Standardization and traceability

The EZ1 AdvancedXL sets new standards in data management. Barcode reading enables complete tracking of samples and reagents throughout the entire purification process. Notes and assay identification information can also be easily entered. For increased process control and reliability, reagent identification and lot numbers are logged together with the expiration date, and a warning is issued if the expiration date has been exceeded. The run report, automatically generated at the end of each protocol, contains allrelevant instrument information, including maintenance procedures and decontamination data. The instruments generate a pdf and a csv file after each run. Data can beeasily transferred to a printer or computer within the network and the report file can be subsequently processed by a LIMS (Laboratory Information Management System).

Proven technology with improved performance

Proven EZ1 Kits, in combination withEZ1 Advanced XL Cards, ensure high-performance results in purification procedures. The unrivaled ease of use of theEZ1 Advanced XL enables fast and reproducible purification, without the need for specialized training or previousexperience with laboratory automation. The extensive application range, including DNA purification from blood, tissues, and human identity and forensic samples, RNA purification from cells and tissues, and purification of viral nucleic acids from a range of sample types, delivers the flexibility that is essential for laboratories.

Safety and reliability

TheEZ1 Advanced XL has been designed to ensure high process safety, high performance, and user convenience. A sensor ensures that theinstrument door remains closed during sample preparation, reducing contact of laboratory personnel with potentially infectious samples and protecting sample integrity. At the end of each run, an intelligent-design UV lamp decontaminates the inner surface of the instrument. UV decontamination is highly effective in eliminating Gram-positive and Gram-negative bacteria (see tables). If required, the instrument can be placed in a safety cabinet, providing increased user safety.

Automated sample preparation enables efficient, standardized purification of nucleic acids. Manual sample handling is minimized, ensuring safety to the user and reliable processing of samples.

The EZ1 Advanced XLinstrument uses proven EZ1 Kits for purification of DNA, RNA, and viral nucleic acids from a wide range of starting materials. Purified nucleic acids are ready for immediate use in downstream applications. The combination of an easy-to-use instrument, with error-free protocol selection and worktable setup, and prefilled, sealed reagent cartridges makes nucleic acid purification easy.

Flexibility and ease of use

The self-contained EZ1 Advanced XL instrument ensures optimal ease of use and walkaway automation. A wide range of protocols is available for purification of DNA, RNA, or viral nucleic acids. Up to 14 samples can be processedper runin as little as20 minutes. Theinstrument is operated via a keypad, andinstrument information is displayed on the VFD (vacuum fluorescent display).

All processing steps are performed by the instruments— from piercing reagent cartridges to elution of pure nucleic acids. A separate computer is not required for operation, and EZ1 Kits include all reagents and accessories required to process your samples. EZ1 Kits provide prefilled, foil-sealed reagent cartridges that remain sealed until the instrument door is closed and the protocol run started, reducing the risk of contamination during setup.

If desired, up to 4 EZ1 Advanced XL instruments can be connected to an external computer, expandingthroughput up to 56 samples per run. This enables you to easily adapt your laboratory setup to changing sample preparation requirements.

EZ1 Kits and EZ1 Advanced XL Cards for a wide range of applications

The EZ1 Advanced XL uses proven EZ1 Kits with preprogrammed protocols on EZ1 Advanced XL Cards. EZ1 Kits are available for a broad range of applications including work in human identity and forensics, biomedical research, and gene expression analysis (see table).

Nucleic acids purified using the EZ1 Advanced XL are ready for use in a wide range of downstream applications, including:

• Oncology, forensics, and genetic identity testing
• Genotyping
• Infectious disease research, including bacterial genotyping
• Gene expression analysis

Have your throughput demands increased? Do you want to expand your application range or further streamline workflows? Do you need to manage more complex samples? Do you need improved connectivity?

If the answer to any of these questions is yes, then QIAGEN’s trade-in/trade-up program is just right for you!

QIAGEN makes it easy to keep up to speed with the latest automation and sample processing technologies. Simply exchange an old instrument for a new one. Improve your efficiency by trading in a competitor instrument or trading up with an older QIAGEN instrument.

Learn more about trade-in/trade-up opportunities.