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Boston Biochem/Bafilomycin A1/1334/100U

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Boston Biochem

货号 /

1334/100U

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4000-520-616

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Product Details

Citations (51)

Reviews (1)

Biological Activity Technical DataBackground Product DatasheetsCalculators

Biological Activity

Highly potent, selective inhibitor of vacuolar H⁺-ATPases (IC₅₀ = 0.6 - 1.5 nM in bovine chromaffin granules). Selective for v-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H⁺/K⁺-ATPase (P-ATPase). Thought to inhibit autophagy either by blocking autophagosome-lysosome fusion (in H4IIE cells), or by blocking lysosomal degradation.

Technical Data

M.Wt:

622.84

Formula:

C₃₅H₅₈O₉

Solubility:

Soluble to 5 mg/ml in DMSO

Purity:

≥98%

Storage:

Desiccate at -20°C

CAS No:

88899-55-2

The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.Yamamoto et al.Cell Struct.Funct., 1998;23:33
Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes.Fass et al.J.Biol.Chem., 2006;281:36303
Chemistry and stucture activity relationships of bafilomycin A₁, a potent and selective inhibitor of the vacuolar H⁺-ATPase.Gagliardi et al.Curr.Med.Chem., 1999;6:1197

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Citations for Bafilomycin A1

The citations listed below are publications that use Tocris products.Selected citations for Bafilomycin A1 include:

51Citations: Showing 1 - 10

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.Authors: Huang Et al.Autophagy2019;:1
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).Authors: Ho Et al.Autophagy2019;:1
Autophagic cell death restricts chromosomal instability during replicative crisis.Authors: Nassour Et al.Nature2019;565:659
Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.Authors: Sica Et al.Cell Rep2019;27:820
Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes.Authors: Lee Et al.Cell Rep2019;26:2194
Recruitment of LC3 to damaged Golgi apparatus.Authors: Gomes-da-Silva Et al.Cell Death Differ2019;26:1467
Anti-MET VHH Pool Overcomes MET-Targeted Cancer Therapeutic Resistance.Authors: Su Et al.Mol Cancer Ther2019;18:100
Junín virus induces autophagy in human A549 cells.Authors: Vidakovics Et al.PLoS One2019;14:e0218730
Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells.Authors: Sagrillo-Fagundes Et al.PLoS One2019;14:e0202458
Oligodendrocytes express synaptic proteins that modulate myelin sheath formation.Authors: Hughes and AppelNat Commun2019;10:4125

IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential.Authors: Boulakirba Et al.Sci Rep2018;8:256

A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain.Authors: Yuan Et al.J Biol Chem2018;293:11625

Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin.Authors: Persaud Et al.J Cell Sci2018;131

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus.Authors: Liu Et al.Sci Rep2017;7:4543

Ferroquine, the next generation antimalarial drug, has antitumor activity.Authors: Kondratskyi Et al.Sci Rep2017;7:15896

Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.Authors: Niessen Et al.Cell Chem Biol2017;24:1388

Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation.Authors: Jacquin Et al.Autophagy2017;13:854

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.Authors: Dai Et al.Autophagy2017;13:1435

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration.Authors: Nabissi Et al.Oncotarget2016;7:77543

Down regulated lncRNA MEG3 eliminates mycobacteria in macrophages via autophagy.Authors: Pawar Et al.Radiat Oncol2016;6:19416

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.Authors: DeJesus Et al.Elife2016;5

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling.Authors: Choi Et al.Autophagy2016;12:1631

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Authors: Holler Et al.Mol Neurodegener2016;11:46

Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.Authors: Lin Et al.Sci Rep2015;290:3377

Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.Authors: Cao Et al.Int J Mol Sci2015;209:879

Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition.Authors: Kim Et al.Biomed Res Int2015;2015:239764

Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.Authors: Lin Et al.J Clin Invest2015;16:5555

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.Authors: Zhu Et al.J Biol Chem2015;125:1098

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy.Authors: Hsu Et al.Autophagy2015;11:643

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.Authors: Obba Et al.J Cell Biol2015;11:1114

Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation.Authors: Hennel Et al.Mol Biol Cell2014;9:85

Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Authors: Kondratskyi Et al.Cell Death Dis2014;5:e1193

Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.Authors: Verstegen Et al.J Neurosci2014;34:7266

The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.Authors: Gutierrez Et al.J Biol Chem2014;289:33568

Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells.Authors: Said Et al.J Immunol2014;193:6135

Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells.Authors: Manes and PoberJ Immunol2014;193:5809

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.Authors: Huang Et al.Nat Immunol2014;15:846

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.Authors: McAlpine Et al.Autophagy2013;9:361

Characteristics and requirements of basal autophagy in HEK 293 cells.Authors: Musiwaro Et al.Autophagy2013;9:1407

Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts.Authors: Vincenzi Et al.PLoS One2013;8:e65561

Autophagy-mediated turnover of dynamin-related protein 1.Authors: Purnell and FoxBMC Neurosci2013;14:86

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.Authors: Robert Et al.Autophagy2012;8:637

Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens.Authors: Ladoire Et al.Autophagy2012;8:1175

West Nile virus growth is independent of autophagy activation.Authors: Beatman Et al.Virology2012;433:262

Negative regulation of signaling by a soluble form of toll-like receptor 9.Authors: Chockalingam Et al.Eur J Immunol2011;41:2176

Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors.Authors: Ruthel Et al.Toxins (Basel)2011;3:207

Relieving autophagy and 4EBP1 from rapamycin resistance.Authors: Nyfeler Et al.Mol Cell Biol2011;31:2867

Notch post-translationally regulates β-catenin protein in stem and progenitor cells.Authors: Kwon Et al.Nat Cell Biol2011;13:1244

Beta1 integrin-dependent engulfment of Yersinia enterocolitica by macrophages is coupled to the activation of autophagy and suppressed by type III protein secretion.Authors: Deuretzbacher Et al.J Immunol2009;183:5847

Extrasynaptic release of GABA by retinal DArgic neurons.Authors: Hirasawa Et al.J Neurophysiol2009;102:146

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.Authors: Ganesan Et al.PLoS Genet2008;4:e1000298

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Good autophagy inhibitor

By JING HEon 03/27/2020

Application: Species:Human

HT29 cells transfected with ad-mRFP-GFP-LC3 adenovirus after incubation with or without LPS and Baf A1 at different time points.

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