700234 | 6,7-diketolithocholic acid

5ß-cholanic acid-3α-ol-6,7-dione

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Info

6,7-diketolithocholic acid

5ß-cholanic acid-3α-ol-6,7-dione

6,7-Diketolithocholic Acid (6,7-diketoLCA / 6,7-dioxolithocholic acid) is a derivative of the bile acid (BA) lithocholic acid / LCA, carrying two additional oxo substituents at positions 6 and 7. The compound has a role of a human metabolite and is slightly soluble in water and methanol.

Such derivatives of lithocholic acid are formed in cytochrome P450 (CYP) enzyme isoforms CYP3A1 and CYP3A2 - regulated reactions.

Lithocholic acid is a secondary BA. It is produced in the colon by bacteria from the primary BA chenodeoxycholic acid (CDCA) through a reduction process and is usually conjugated with the amino acids taurine or glycine.

LCA and its derivatives, including 6,7-Diketolithocholic Acid, own a wide range of effects in the human body.

Lithocholic acid is proven to have a role in carcinogenesis. The BA shows both antineoplastic and pro-oncogenic properties depending on its concentrations. When present at physiological levels, LCA is suggested to kill neuroblastoma cells and spare normal neuronal cells, at the same time. It is also believed to be cytotoxic to other types of cancerous cells.

However, at sufficiently high concentrations, LCA acts as an oncometabolite, and it promotes neoplastic growth of several cancers - colon, esophageal, pancreatic cancer, and more. In this manner, dietary fiber binds to lithocholic acid and thus enhances its excretion in stool. So, fiber is protective against colon and other gastrointestinal cancers.

Also, LCA and its metabolites, function as detergents that solubilize fats for absorption and transport, can be used as cholagogues, and act as geroprotectors - they show anti-aging effects in numerous analyses. Besides, the compounds implement roles of signaling molecules and are noticed to activate the vitamin D receptor without significantly raising calcium levels.

In addition to all these properties, scientists have discovered that 6,7-Diketolithocholic Acid concentrations increase in patients with cholestasis, which could be used as a diagnostic biomarker.

Avanti Polar Lipids provides quality, pure, and stable 6,7-Diketolithocholic Acid for the best research results.

Data

Hygroscopic

No

Light Sensitive

No

Molecular Formula

C₂₄H₃₆O₅

Percent Composition

C 71.26%, H 8.97%, O 19.77%

Purity

>99%

Stability

1 Year

Storage Temperature

-20°C

CAS Number

1643669-23-1 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

404.55

Exact Mass

404.26

Downloads

• ChemDraw File
• 3D Structure
• Structure
• Safety Data Sheet

References

Certificates of Analysis

• Certificate of Analysis(Lot No. 700234P-1MG-A-010and 6849PGA010)
• Certificate of Analysis(Lot No. 700234P-1MG-B-010and 6849PGB010)
• Certificate of Analysis(Lot No. 700234P-1MG-C-010and 6849PGC010)

AvantiPolarLipids公司是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供1000种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，AvantiPolarLipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。 AvantiPolarLipids,Inc.,hasalonghistoryof50yearscreatingthehighestpuritylipidsavailable.Ourpassionforhighqualityanduniqueproductsisonlyexceededbyourexcellentreputationinthemarketplace. Althoughweareknownforourlipids,weareMorethanLipids.Weoffersolutionsfortheentireproductcycle…ResearchtoCommercialization. AvantiPolarLipids公司的主要产品和服务包括：（1）ResearchProductsHighestPurityLipidReagents（2）cGMPManufacturingAPI&ContractManufacturing（3）AdjuvantsImmunotherapy&VaccineDevelopment（4）AnalyticalServicesLipidAnalysis（5）LipidomicsMassSpecStandards,Antibodies&LipidToolbox（6）Formulationsliposomes&Nanoparticles（7）EquipmentLiposomeProductionTools（8）CustomServicesSynthesis&Beyond

AvantiPolarLipids是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供1000种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，AvantiPolarLipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。

AvantiPolarLipidsInc,是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至百公斤级的磷脂类和甾体类中间体和试剂。主要产品Naturalsphingolipids天然鞘脂类Naturalphospholipids天然磷脂类Naturallipidsbyextraction天然提取脂类Referencestandards相关标准品Syntheticsphingolipids合成鞘脂类--Sphingosines&S-1-P鞘氨醇和鞘氨醇-1-磷酸盐--Ceramides神经酰胺--Sphingomyelins鞘磷脂--Sphingosine&ceramidederivatives鞘氨醇及神经酰胺衍生物--Sphinganine&derivatives鞘氨醇及其衍生物--C17sphingolipids十七碳鞘脂类--C20sphingolipids二十碳鞘脂类--Phytosphingosine&derivatives植物鞘氨醇及其衍生物Syntheticlipids&phospholipids合成脂质与磷脂--PC卵磷脂--PA磷脂酸--PE脑磷脂--PG磷脂酰甘油--PS磷脂酰丝氨酸--PI,PIP2&PIP3磷脂酰肌醇，磷脂酰肌醇-4,5-二磷酸，磷脂酰-3,4,5-三磷酸--CA胆酸--LysoPC溶源性卵磷脂--LysoPA溶源性磷脂酸--LysoPAAnalogues溶源性磷脂酸类似物--Lysobio-PA溶源性双磷脂酸--LysoPE,PG&PS溶源性脑磷脂，磷脂酰甘油和磷脂酰丝氨酸--AlkylPC烷基卵磷脂--Diether&Diphytanoyletherlipids二醚与二植烷醚脂质--PAF血小板活化因子--AcylPAFAnalog酰化血小板活化因子类似物--Brominatedphosphocholines溴代胆碱磷酸--Alkylphosphatederivatives烷基磷酸盐衍生物--Plasmalogen缩醛磷脂--Functionalizedlipids功能性脂类--Biotinylatedlipids生物素酰化脂质--Bioactivelipids生物活性脂类Syntheticphospholipids合成磷酸--AcylcoenzymeA乙酰辅酶A--Metabolicintermediates代谢中间产物--Adhesivelipid粘合脂质--pHsensitivelipids酸度计用脂质Transfectionreagents转染试剂Sterolderivatives甾酮衍生物Lipidblends混合脂质Glycosylatedphospholipids糖化磷脂Fluorinatedphospholipids氟化磷脂Chelators螯合剂Pre-mixedlipidsforbicelleformation构型分析用预混合脂质Diacylglycerols&analogues甘油二酯与类似物Deuteriumlabeledlipids氘标记脂质C13PC碳-13标记卵磷脂DoxylPC自旋标记卵磷脂TempoPCTempo（4-氧-4-羟-四甲基呱啶氮氧自由基）标记卵磷脂Fluoresecentsphingolipids荧光标记鞘脂类--Omegalabeled欧米加标记物--Fattyacidlabeled脂肪酸标记物Fluoresecentcholesterol荧光标记胆固醇Fluoresecentphospholipids荧光标记磷脂--Fattyacidlabeled脂肪酸标记物--Headgrouplabeled首基标记物Polymerizablelipids聚合脂质Poly（Ethyleneglycol）-lipidconjugates共轭聚脂质FunctionalizedPEGlipids功能PEG脂质Analyticalservices分析服务Drugdeliveryproduct药物运送载体Bulklipidsforpharmaceuticalproduction工业级脂质Equipment设备