870621 | 18:0-PhoDAG

1-stearoyl-2-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-sn-glycerol

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Info

18:0-PhoDAG

1-stearoyl-2-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-sn-glycerol

Diacylglycerols (DAG) play a key role in transient receptor potential (TRP) channels. TRP channels are linked to a wide variety of biological processes including the body"s ability to sense and process pain, temperature, tastes, pressure, and vision. 18:0 PhoDAG is embedded with a photoswitchable azobenzene moiety that allows rapid photoactivation of these DAG-sensitive TRP channels. The photoswitchable DAG allows for the further exploration of the physiological relevance of these TRP channels in the body’s homeostasis process.

Leinders-Zufall, T., Storch, U., Bleymehl, K.; et. al. PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels. Cell Chem. Bio. 2020 Dec 21; 2(25): 215-223. https://doi.org/10.1016/j.chem...

Data

Hygroscopic

No

Light Sensitive

Yes

Molecular Formula

C₄₁H₆₄N₂O₅

Percent Composition

C 74.06% H 9.70% N 4.21% O 12.03%

Purity

>99%

Stability

One Year

Storage Temperature

-20°C

CAS Number

1985595-31-0 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

664.97

Exact Mass

664.48

Downloads

• ChemDraw File
• 3D Structure
• Structure

References

Zhang X, Barraza KM, Upton KT, Beauchamp JL. Subtle Changes in Lipid Environment Have Profound Effects on Membrane Oxidation Chemistry. J Am Chem Soc. 2018 Nov 21. doi: 10.1021/jacs.8b08610. [Epub ahead of print]

PubMed ID: 30461271

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Certificates of Analysis

• Certificate of Analysis(Lot No. 870621P-25MG-A-010and 6497PJA010)
• Certificate of Analysis(Lot No. 870621P-5MG-A-010and 6497PHA010)
• Certificate of Analysis(Lot No. 870621P-25MG-A-011and 6497PJA011)
• Certificate of Analysis(Lot No. 870621P-5MG-A-011and 6495PHA011)

AvantiPolarLipids公司是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供1000种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，AvantiPolarLipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。 AvantiPolarLipids,Inc.,hasalonghistoryof50yearscreatingthehighestpuritylipidsavailable.Ourpassionforhighqualityanduniqueproductsisonlyexceededbyourexcellentreputationinthemarketplace. Althoughweareknownforourlipids,weareMorethanLipids.Weoffersolutionsfortheentireproductcycle…ResearchtoCommercialization. AvantiPolarLipids公司的主要产品和服务包括：（1）ResearchProductsHighestPurityLipidReagents（2）cGMPManufacturingAPI&ContractManufacturing（3）AdjuvantsImmunotherapy&VaccineDevelopment（4）AnalyticalServicesLipidAnalysis（5）LipidomicsMassSpecStandards,Antibodies&LipidToolbox（6）Formulationsliposomes&Nanoparticles（7）EquipmentLiposomeProductionTools（8）CustomServicesSynthesis&Beyond

AvantiPolarLipids是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供1000种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，AvantiPolarLipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。

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