Abcam/Recombinant human IGF1 protein (Active) (ab270062)/1/Active) (ab270062_蚂蚁淘，【正品极速】生物医学科研用品轻松购|ebiomall 蚂蚁淘商城

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Abcam/Recombinant human IGF1 protein (Active) (ab270062)/1/Active) (ab270062

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Abcam/Recombinant human IGF1 protein (Active) (ab270062)/1/Active) (ab270062

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Abcam

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Active)(ab270062

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Product name
Recombinant human IGF1 protein (Active)See all IGF1 proteins and peptides
Biological activity
Fully biologicaly active as determined by dose-depended proliferation of MCF-7 cells.
ED₅₀ is ≤ 0.9 ng/mL, corresponding to a specific activity of 1.11 x 10⁶ units/mg.
Purity
>= 95% Immunogen affinity purified.Purity by HPLC >=95%.
Endotoxin level
<>
Expression system
HEK 293 cells
Accession
P05019
Protein length
Full length protein
Animal free
Yes
Carrier free
Yes
Nature
Recombinant
- Species
  Human
- Sequence
  GP ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSA
- Predicted molecular weight
  8 kDa
- Molecular weight information
  M - 2.84 Da (Calculated mass 7711.84 Da)GP ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSA
- Amino acids
  49 to 118
- Additional sequence information
  N-terminal glycineFull-length mature chain lacking the signal peptide and both pro-peptides.

Our Abpromise guarantee covers the use ofab270062in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications
Cell Culture
SDS-PAGE
HPLC
Mass Spectrometry
Functional Studies
Form
Lyophilized
Additional notes
This protein is filter sterilized prior to aliquoting and lyophilization. All aliquoting and lyophilization steps are performed in a sterile environment
Concentration information loading...

Stability and Storage
Shipped at Room Temperature. Store at Room Temperature.
Information available upon request.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitution
Reconstitute with phosphate buffered saline.Store lyophilized form at room temperature. Reconstitute, aliquot and store at -80°C for 12 months or +4°C for 1 week.Avoid repeated freeze-thaw.

Alternative names
- IBP1
- IGF I
- IGF IA
- IGF IB
- IGF-I
- Igf1
- IGF1_HUMAN
- IGF1A
- IGFI
- IGFIA
- Insulin like growth factor 1
- Insulin like growth factor 1 (somatomedin C)
- Insulin like growth factor IA
- Insulin like growth factor IB
- Insulin-like growth factor I
- Mechano growth factor
- MGF
- OTTHUMP00000195080
- OTTHUMP00000195081
- OTTHUMP00000195082
- OTTHUMP00000195083
- OTTHUMP00000195084
- Somatomedia C
- Somatomedin C
- Somatomedin-C
see all
Function
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
Involvement in disease
Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
Sequence similarities
Belongs to the insulin family.
Cellular localization
Secreted.
Target information above from: UniProt accessionP05019The UniProt ConsortiumThe Universal Protein Resource (UniProt) in 2010Nucleic Acids Res. 38:D142-D148 (2010).
Information by UniProt

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