+,MAR,MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2蚂蚁淘商城

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ACROBiosystems/Human MARCO Protein, His Tag/1mg/MAR

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ACROBiosystems/Human MARCO Protein, His Tag/1mg/MAR

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ACROBiosystems

货号 /

MAR

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4000-520-616

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This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.

Synonym
MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2
Source
Human MARCO, His Tag (MAR-H5249) is expressed from human 293 cells (HEK293). It contains AA Val 65 - Val 520 (Accession # Q9UEW3-1).
Predicted N-terminus: His
Molecular Characterization
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 47.4 KDa.
Endotoxin

Formulation
Please contact us for detailed information.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70^°C for 3 months under sterile conditions after reconstitution.

Background
MARCO is also known as Scavenger receptor class A member 2 and SCARA2. Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2. MARCO ligation promotes the production of inflammatory mediators by macrophages. MARCO mediated internalization of some ligands prevents their activation of cell surface TLR4 but enables their activation of intracellular TLR3. MARCO contributes to the clearance of apoptotic cells and inhaled bacteria, mast cell mediated silicosis, and the amelioration of allergen or ozone induced lung inflammation. It is required for the organization of the splenic marginal zone and the interaction of splenic macrophages and B cells.
References
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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