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Sino Biological/Anti-RND3 Antibody, Rabbit Polyclonal/1/101056-T32

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Sino Biological/Anti-RND3 Antibody, Rabbit Polyclonal/1/101056-T32

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Sino Biological

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101056-T32

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Anti-RND3 Antibody, Rabbit Polyclonal General Information

Product name

Anti-RND3 Antibody, Rabbit Polyclonal

Validated applications

Species reactivity

Reacts with: Human Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)

Specificity

Human RND3

Immunogen

A synthetic peptide corresponding to the C-terminus of the Human RND3

Preparation

Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human RND3, and purified by antigen affinity chromatography.

Source

Polyclonal Rabbit IgG

Purification

Protein A & Antigen Affinity

Formulation

0.2 μm filtered solution in PBS

Conjugate

Unconjugated

Form

Liquid

Shipping

This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-RND3 Antibody, Rabbit Polyclonal Validated Applications

Application	Dilution
WB	1:500-1:1000

Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-RND3 Antibody, Rabbit Polyclonal Images

Anti-RND3 rabbit polyclonal antibody at 1:500 dilution

Lane A: NCI-H460 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800)at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:27 kDa

Observed band size:30 kDa

Anti-RND3 Antibody, Rabbit Polyclonal: Synonyms

Anti-ARHE Antibody; Anti-memB Antibody; Anti-Rho8 Antibody; Anti-RhoE Antibody

RND3 Background Information

Forced expression of RND3 inhibited Snail1 activity, which in turn blocked glioblastoma cell migration and invasion in vitro in cell culture and in vivo in GBM xenograft mice. Activation of Notch signaling contributes to glioblastoma multiform (GBM) tumorigenesis. The downregulation of RND3 is responsible for the enhancement of Notch activity that promotes glioblastoma genesis.

Full Name

Rho family GTPase 3

Counteracting Genome Instability by p53-dependent Mintosis
Author
Liang, J;Niu, Z;Yu, X;Zhang, B;Wang, M;Ruan, B;Qin, H;
Year
2020
Journal
bioRxiv
Application
WB
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