
Overview:
EIF2AK2 (also known as double-stranded RNA-activated protein kinase and PKR) is a protein kinase that is involved in HIV/gp120-associated neurodegeneration (1). EIF2AK2 is a mediator of gp120 neurotoxicity and is a substrate for a family of protein kinases involved in environmental stress responses. Activation of EIF2AK2 by dsRNA leads to autophosphorylation at Thr446/451. Activated EIF2AK2 phosphorylates the alpha subunit of EIF2, which in turn inhibits protein synthesis. EIF2AK2 plays a critical role in mRNA translation, cell proliferation and apoptosis. Crosstalk between EIF2AKs and p53 has implications in cell proliferation and tumorigenesis (2).
References:
1. Baltzis, D. et al: The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. J. Biol Chem. 2007; 282(43):31675-87 2. Alirezaei, M. et al: Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. J. Neurosci. 2007;27(41):11047-55.
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而国内的只有兔抗牛。
就二抗来说,国内的标记二抗质量也很不错。可以用。
有没有知道哪个公司可以买到几种牛病毒的荧光标记的抗体?
我要做细胞的免疫荧光实验。
1.Bluetongue蓝舌病毒
2.BovineAdenovirus牛腺病毒
3.BovineParvovirus牛细小病毒
4.BovineRespiratorySyncytialVirus牛呼吸道融合病毒
5.BovineVirusDiarrhoea牛腹泻病毒
6.Reovirus呼肠孤病毒-3
7.InfectiousBovineRhinotracheitis,IBR传染性牛鼻气管炎病毒
8.BovineParainfluenzaVirusType3,PI3牛副流行性感冒3型病毒
9.RABIes狂犬病毒
能提供一种的也可以,多谢啊~~~~~~~

