豚鼠皮肤成纤维样细胞;2011104S安防展览网
ProductSpecification:
| AlternativeName: | PAR-4 |
| Host: | Rabbit |
| Immunogen: | Syntheticpeptidecorrespondingtoaa136-150(withaC149Sreplacement)ofhumanPAR-4(proteinase-activatedreceptor-4). |
| UniProtID: | Q96RI0 |
| Speciesreactivity: | Human,Rat |
| Applications: | FlowCytometry,ICC,IHC,WB |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | PAR-4belongstoafourmemberfamilyofGprotein-coupledreceptors(PAR-1to-4)thatareactivatedasaresultofproteolyticcleavagebycertainserineproteases,hencetheirname.Inthismodalityofactivation,aspecificproteinasecleavesthePARreceptorwithinadefinedsequenceinitsextracellularN-terminaldomain.ThiscleavageresultsinthecreationofanewN-terminalsequence(tetheredligand),whichsubsequentlybindstoasiteinthesecondextracellularloopofthesamereceptor.ThisbindingresultsinthecouplingofthereceptortoGproteinsandintheactivationofseveralsignaltransductionpathways1-3DifferentPARsareactivatedbydifferentproteinases.PAR-4isactivatedbyboththrombinandtrypsinwhereasPAR-1andPAR-3areactivatedbythrombinandPAR-2isactivatedbytrypsin1-3.PAR-4canbealsocleavedandactivatedbyotherproteinasessuchascathepsinG.TheintracellularsignalingmechanismsmediatedbyPAR-4activationarenotcompletelyelucidatedbuttheymayinvolvecalciummobilizationdownstreamofphospholipaseCthroughtheGαqpathway1-3TissuedistributionofPAR-4isverybroadwiththehighestexpressionlevelsfoundinlung,testis,pancreasandsmallintestine.Inaddition,PAR-4expressionwasobservedinplatelets,megakaryocytesandleukocytes.StudieswithplateletsderivedformPAR-4knockoutmicehaveestablishedanessentialroleforPAR-4inthrombin-inducedplateletactivation.PAR-4islikelyinvolvedinotherphysiologicalfunctionssuchasregulationofgastrointestinalmotilityandregulationofvascularendothelialcellfunction1-3. |
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发布于 ： 2018-03-23
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