Tocris/NSC 319726/5065/50/50 mg
Biological Activity
Reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.
Compound Libraries
NSC 319726 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 234.32 |
| Formula | C11H14N4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 71555-25-4 |
| PubChem ID | 5351307 |
| InChI Key | XDHBUMNIQRLHGO-UKTHLTGXSA-N |
| Smiles | C/C(C1=NC=CC=C1)=NNC(N2CCC2)=S |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 23.43 | 100 |
| ethanol | 2.34 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 234.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 4.27 mL | 21.34 mL | 42.68 mL |
| 5 mM | 0.85 mL | 4.27 mL | 8.54 mL |
| 10 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Yu et al (2012) Allele-specific p53 mutant reactivation. Cancer Cell 21 614 PMID: 22624712
Keywords: NSC 319726, supplier, NSC319726, mutant, p53, reactivators, activators, p53R175, transcription, factors, cell, cycle, apoptosis, p53, p53, Tocris Bioscience
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