Tocris/Pyridostatin pentahydrochloride/4763/50/50 mg
Biological Activity
Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
Technical Data
| M. Wt | 778.94 |
| Formula | C31H32N8O5.5HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| PubChem ID | 78243739 |
| InChI Key | SRIZPFGTXSQRFM-UHFFFAOYSA-N |
| Smiles | NCCOC1=CC(C(NC2=NC(C=CC=C3)=C3C(OCCN)=C2)=O)=NC(C(NC4=CC(OCCN)=C(C=CC=C5)C5=N4)=O)=C1.Cl.Cl.Cl.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| water | 77.89 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 778.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 1.28 mL | 6.42 mL | 12.84 mL |
| 5 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 10 mM | 0.13 mL | 0.64 mL | 1.28 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.26 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Rodriguez et al (20112) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat.Chem.Biol. 8 301 PMID: 22306580
Müller et al (2010) Small-molecule-mediated G-quadruplex isolation from human cells. Nat.Chem. 2 1095 PMID: 21107376
Koirala et al (2011) A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat.Chem. 3 782 PMID: 21941250
Keywords: Pyridostatin pentahydrochloride, supplier, Pyridostatin, 5HCl, stabilizes, G-quadruplexes, DNA, damage, cell, cycle, arrest, proto-oncogene, SRC, telomerase, telomeric, DNA-dependent, protein, kinase, catalytic, DNA-PKcs, sunbunit, Cell, Cycle, Inhibitors, Checkpoint, Control, Kinases, Src, Kinases, Cell, Cycle, Inhibitors, Tocris Bioscience
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