Annotated and awaiting review. Please contact us if you can help with reviewing. Download all structure-activity data for this target as a CSV file The supplementary information from Cee et al. (2009) identifies the protein they refer to as CDK11 in the article text, as Entrez gene symbol CDC2L6 which is in fact CDK19, a close relation of CDK8 [1]. 1. Cee VJ, Chen DY, Lee MR, Nicolaou KC.(2009)Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11. 2. Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, Czodrowski P, Musil D et al..(2015)A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. 3. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP.(2011)Comprehensive analysis of kinase inhibitor selectivity. 4. Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS.(2018)Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. 5. Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R et al..(2016)2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. 6. Tap WD, Wainberg ZA, Anthony SP, Ibrahim PN, Zhang C, Healey JH, Chmielowski B, Staddon AP, Cohn AL, Shapiro GI et al..(2015)Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. 7. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al..(2010)Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. CDK8 subfamily: cyclin dependent kinase 19. Last modified on 05/04/2018. Accessed on 18/05/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1972.