Product overview

• NameCFM-2
• Short descriptionSelective, non-competitive AMPA receptor antagonist
• Biological descriptionSelective and non-competitive AMPA receptor antagonist. Inhibits ERK1/2 pathway and acts as an antiproliferative agent. Also shows anticonvulsant actions.
• Biological actionAntagonist
• Purity>98%
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Properties

• Chemical name1-(4-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one
• Molecular Weight311.34
• Chemical structure
• Molecular FormulaC₁₇H₁₇N₃O₃
• CAS Number178616-26-7

Storing and Using Your Product

• Storage instructionsroom temperature
• Solubility overviewsoluble in DMSO (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CFM-2

• Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats.

  De Sarro G et al (1999)Eur J Pharmacol 368(2-3) : 149-59. PubMedID: 10193651

• AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth.

  Stepulak A et al (2007)Cancer Biol Ther 6(12) : 1908-15. PubMedID: 18059166

• 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

  Chimirri A et al (1997)J Med Chem 40(8) : 1258-69. PubMedID: 9111300