Product overview

• Name(RS)-MCPG
• Short descriptionNon-selective group I and II mGluR antagonist
• Biological description

  Non-selective group I and II mGluR antagonist.

  Also competitive antagonist of ACPD sensitive receptors.

  Shows no effect on locomotor activity.

  Water soluble (R,S)-MCPG sodium salt and (S)-MCPG sodium salt also available. (S)-MCPG also available.

• Biological actionAntagonist
• Purity>98%
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Properties

• Chemical name(RS)-α-Methyl-4-carboxyphenylglycine
• Molecular Weight209.2
• Chemical structure
• Molecular FormulaC₁₀H₁₁NO₄
• CAS Number146669-29-6
• PubChem identifier1222
• SMILESCC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
• SourceSynthetic
• InChiInChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h4-5H,11H2,1H3,(H,12,13)(H,14,15)
• InChiKeyDNCAZYRLRMTVSF-UHFFFAOYSA-N
• MDL numberMFCD00210205
• AppearanceWhite solid

Storing and Using Your Product

• Storage instructionsRoom temperature
• Solubility overviewSoluble in 0.1M NaOH (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (RS)-MCPG

• The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats.

  Kim JH et al (1998)Neuropharmacology 37(2) : 189-97. PubMedID: 9680243

• MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus.

  Manzoni OJ et al (1994)Eur J Neurosci 6(6) : 1050-4. PubMedID: 7952274

• Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.

  Eaton SA et al (1993)Eur J Pharmacol 244(2) : 195-7. PubMedID: 8381746