Adipogen/anti-Nampt (Visfatin/PBEF), mAb (OMNI379)/AG-20A-0034-C100/100 µg
| Pre-B Cell Colony Enhancing Factor 1; PBEF1; Nicotinamide Phosphoribosyltransferase |
| Monoclonal Antibody |
| OMNI379 |
| Mouse IgG2aκ |
| Recombinant human Nampt (visfatin/PBEF). |
| ELISA: (direct or indirect: 1:2000-1:10000)Flow Cytometry: (1:1000)Immunocytochemistry: (1:500-1:1’000)Immunohistochemistry: (paraffin sections, 1:100-1:500)Immunoprecipitation: (1:500-1:1’000)Western blot: (1:2000-1:5000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature).Optimal conditions should be determined individually for each application. |
| HumanMouseRat |
| Recognizes human, mouse and rat Nampt. |
| Protein G-affinity purified. |
| 1mg/ml |
| Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| BLUE ICE |
| +4°C |
| -20°C |
| After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles. |
| Stable for at least 1 year after receipt when stored at -20°C. |
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Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
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