Adipogen/CD83 (human):Fc (human) (rec.) (non-lytic)/CHI-HF-220CD83-C100/100 µg
More Information Product Details
Product Type | Protein |
Properties
Source/Host | CHO cells |
Sequence | The extracellular domain of human CD83 (aa 20-131) is fused to the N-terminus of the Fc region of a mutant human IgG1. |
Crossreactivity | Human |
Biological Activity | Shows the biological function of the CD83 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. |
Purity | ≥98% (SDS-PAGE) |
Endotoxin Content | |
Reconstitution | Reconstitute at 100μg/ml in sterile PBS. |
Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
Other Product Data | Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).NCBI reference NP_004224.1: CD83 (human) |
Declaration | Manufactured by Chimerigen. |
Shipping and Handling
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Avoid freeze/thaw cycles. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C. |
Documents
MSDS | No |
Product Specification Sheet
Datasheet ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Human CD83 is a 40-50 kDa member of the Siglec (or sialic-acid-binding immunoglobulin-like lectin) family of transmembrane proteins. CD83 is a primary marker for dendritic cells. It is also found on B cells, neutrophils, monocytes and macrophages. Except for dendritic cells, CD83 expression is often transient. CD83 binds to sialic acids on target cells. Membrane CD83 promotes T cell proliferation, particularly of CD8
+ cytotoxic T cells. Soluble CD83 is immunosuppressive and blocks T cell activation. On monocytes, CD83 is suggested to drive monocytes into a fibrocyte phenotype. A lack of membrane-expressed CD83 leads to an unusual IL-4/ IL-10 producing CD4
+ T cell phenotype.
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