Adipogen/PF-562271/SYN-1064-M050/50 mg-蚂蚁淘商城

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Adipogen/PF-562271/SYN-1064-M050/50 mg

2025-06-25

More Information Product Details Synonyms Product Type Properties Formula MW CAS Purity Chemicals Appearance Solubility Declaration Other Product Data InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Use/Stability Documents MSDS Product Specification Sheet Datasheet

PF562271

Chemical

C₂₁H₂₀F₃N₇O₃S

507.5

717907-75-0

≥95%

Solid.

Soluble in DMSO or ethanol.

Manufactured by SynKinase.

Target: FGFR | Kinase Group: RTK | Substrate: TyrosineClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

MZDKLVOWGIOKTN-UHFFFAOYSA-N

AMBIENT

+4°C

-20°C

Stable for at least 2 years after receipt when stored at -20°C.

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PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.Product References

Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271: W.G. Roberts, et al.; Cancer Res. 68, 1935 (2008)

Selectivity data: assessment, predictions, concordance, and implications. C. Gao, et al.; J. Med. Chem. 56, 6991 (2013)

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