Adipogen/anti-Amphiphysin, mAb (N8-2)/YIF-LF-MA0047/100 µl
More Information Product Details
Synonyms | AMPH; AMPH1; Amphiphysin |
Product Type | Monoclonal Antibody |
Properties
Clone | N8-2 |
Isotype | Mouse IgG1 κ |
Immunogen/Antigen | Recombinant human GST-fragment protein (1-347AA) purified from E. coli. |
Application | Western Blot (1:2,000)Immunoprecipitation (1~2 μl)IHC-P (1:100)ICC (1:100) |
Crossreactivity | HumanMouseRat |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Other Product Data | Click here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet. |
Declaration | Manufactured by AbFrontier |
Shipping and Handling
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents
MSDS | No |
Product Specification Sheet
Datasheet ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome. May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.Product References1) Zhang, B. and Zelhof, A.C. (2002) Traffic, 3:452-460. (General)2) Wigge, P. and McMahon, H.T. (1998) Trends Neurosci. 21, 339-344. (General)
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