Product Name:

Tropisetron CAS No.:

89565-68-4Cat. No.:

HY-B0072

Product Data Sheet

MWt:

284.35Formula:

C17H20N2O2Purity :>98%

Solubility:

DMSO

y Mechanisms:Biological Activity:

Tropisetron is a selective 5HT3receptor antagonist and 7nicotinic receptor agonist with an IC50

Pathways:GPCR/G protein; Target:5-HT Receptor Pathways:Neuronal Signaling; Target:5-HT Receptor Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50of 70.1 ± 0.9 nM for 5-HT3 receptor. It is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.

References:

[1]. Zhang Z, Zhuang Y, Ouyang F, Zhang A, Zeng B, Gu M. Penehyclidine enhances the efficacy of tropisetron in prevention of PONV following gynecological laparoscopic surgery. J Anesth. 2012 Aug

10.[2]. Alimoradi H, Barzegar-Fallah A, Hassanzadeh G, Mohammadi-Rick S, Asadi F, Delfan B, Abbasi A, Dehpour AR. The Cardioprotective Effects of an Antiemetic Drug, Tropisetron, on ,p p g,p ,

Cardiomyopathy Related to Doxorubicin. Cardiovasc Toxicol. 2012 Jun 29.[3]. Stratz C, Bhatia HS, Akundi RS, Nührenberg T, Trenk D, Mu?oz E, Fiebich BL. The anti-

inflammatory effects of the 5-HT(3) receptor antagonist tropisetron are mediated by the inhibition of

p38 MAPK activation in primary human monocytes. Int Immunopharmacol. 2012 Aug;13(4):398-402.[4]. Liu FC, Hwang TL, Liu FW, Yu HP. Tropisetron attenuates cardiac injury in a rat trauma-hemorrhage model. Shock. 2012 Jul;38(1):...

Caution: Not fully tested. For research purposes only

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