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MedKoo Biosciences/YL-109/406591/100mg-蚂蚁淘商城
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MedKoo Biosciences/YL-109/406591/100mg

  
  2026-07-31
  
YL-109 has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo. YL-109 repressed the sphere-forming ability and the expression of stem cell markers in MDA-MB-231 mammosphere cultures. YL-109 increased the expression of carboxyl terminus of Hsp70-interacting protein (CHIP), which suppresses tumorigenic and metastatic potential of breast cancer cells by inhibiting the oncogenic pathway. YL-109 induced CHIP transcription because of the recruitment of the aryl hydrocarbon receptor (AhR) to upstream of CHIP gene in MDA-MB-231 cells. Consistently, the antitumor effects of YL-109 were depressed by CHIP or AhR knockdown in MDA-MB-231 cells. YL-109 inhibits cell growth and metastatic potential by inducing CHIP expression through AhR signaling and reduces cancer stem cell properties in MDA-MB-231 cells.

MedKoo Cat#: 406591Name: YL-109CAS#: 36341-25-0Chemical Formula: C14H11NO2SExact Mass: 257.05105Molecular Weight: 257.31Elemental Analysis: C, 65.35; H, 4.31; N, 5.44; O, 12.44; S, 12.46

Synonym:YL109; YP-109; YP 109.

IUPAC/Chemical Name:4-(benzo[d]thiazol-2-yl)-2-methoxyphenol

SMILES Code:COC1=CC(C2=NC3=CC=CC=C3S2)=CC=C1O

Technical Data

Appearance:Solid powder

Purity:>98% (or refer to the Certificate of Analysis)

Certificate of Analysis: View CoA: current batch, Lot#CRB60304

QC Data: View QC data: current batch, Lot#CRB60304

Safety Data Sheet (MSDS): View Material Safety Data Sheet (MSDS)

Shipping Condition:Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:Soluble in DMSO, not in water

Shelf Life:>2 years if stored properly

Drug Formulation:This drug may be formulated in DMSO

Stock Solution Storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:293490

Additional Information

        

References

 1: Hiyoshi H, Goto N, Tsuchiya M, Iida K, Nakajima Y, Hirata N, Kanda Y, Nagasawa K, Yanagisawa J. 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP. Sci Rep. 2014 Nov 18;4:7095. doi: 10.1038/srep07095. PubMed PMID: 25403352; PubMed Central PMCID: PMC4235287.

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