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MedKoo Biosciences/GSK-1904529a/401480/500mg
2020-10-12
GSK-1904529A, also known as GSK 4529, is an IGF-1R Inhibitor, is is a promising candidate for therapeutic use in IGF-IR–dependent tumors. GSK1904529A selectively inhibits IGF-IR and IR with IC50s of 27 and 25 nmol/L, respectively. GSK1904529A blocks rece[查看详情]
MedKoo Biosciences/Ridaforolimus/200860/2g
2020-10-04
Ridaforolimus, also known as AP23573, MK-8669 Deforolimus, is an investigational targeted and small-molecule inhibitor of the protein mTOR, a protein that acts as a central regulator of protein synthesis, cell proliferation, cell cycle progression and cel[查看详情]
MedKoo Biosciences/Pinometostat (EPZ-5676)/205892/100mg
2020-06-10
Pinometostat, also known as EPZ-5676, is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT[查看详情]
MedKoo Biosciences/Topotecan HCl/100870/500mg
2020-05-27
Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-s[查看详情]
MedKoo Biosciences/Bromosporine/406459/2g
2024-03-13
Bromosporine is a broad spectrum inhibitor for bromodomains and as such will be very useful in elucidating further biological roles of reader domains as well as a tool for the validation of functional assays. Proteins that contain BRDs have been implicate[查看详情]
MedKoo Biosciences/Rivaroxaban/300310/25g
2020-05-27
Rivaroxaban, also known as BAY 59-7939, is an oral anticoagulant invented and manufactured by Bayer; in a number of countries it is marketed as Xarelto. If approved by the United States FDA, it will be marketed by Ortho-McNeil Pharmaceutical. It is the fi[查看详情]
MedKoo Biosciences/ARQ-501 (beta lapachone)/200284/50mg
2020-07-19
ARQ-501 is a naphthoquinone compound derived from bark of Tabebuia sp., with antitumor, antibacterial, antifungal and antitrypanosomal activities. Beta-lapachone exerts its anti-tumor effect by indirect actions of inducing p53-independent apoptosis and ce[查看详情]
MedKoo Biosciences/GSK143/406269/100mg
2020-10-21
GSK143 is a potent and highly selective SYK inhibitor showing good efficacy in the rat Arthus model. The Syk inhibitor GSK143 reduces macrophage activation and mast cell degranulation in vitro. In addition, it inhibits manipulation-induced intestinal musc[查看详情]
MedKoo Biosciences/OSI-930/202100/2g
2020-10-29
OSI-930 is a selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which m[查看详情]
MedKoo Biosciences/TAE684/202045/1g
2020-11-09
TAE684, also known as NVP-TAE684, is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC(50) values between 2 and 10 nM . TAE684 is also a potent inhibitor of LRRK2 kina[查看详情]
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