Linopirdine | CAS#105431-72-9 | cognitive enhancer

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Linopirdine | CAS#105431-72-9 | cognitive enhancer | MedKoo

2026-07-31

Linopirdine is a cognitive enhancer. It acts by stimulating release of acetylcholine and other neurotransmitters. Price and Availability

Linopirdine, purity 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. InChI=1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2SMILES Code: O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C1(CC4=CC=NC=C4)CC5=CC=NC=C5 Technical Data Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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13: Engholm M, Pinilla E, Mogensen S, Matchkov V, Hedegaard ER, Chen H, Mulvany MJ, Simonsen U. Involvement of transglutaminase 2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries. Br J Pharmacol. 2016 Mar;173(5):839-55. doi: 10.1111/bph.13393. Epub 2016 Jan 27. PubMed PMID: 26603619; PubMed Central PMCID: PMC4761098.

14: Sakakibara K, Feng GG, Li J, Akahori T, Yasuda Y, Nakamura E, Hatakeyama N, Fujiwara Y, Kinoshita H. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7. doi: 10.1016/j.jphs.2015.07.042. Epub 2015 Aug 10. PubMed PMID: 26318674.

15: Abd-Elsayed AA, Ikeda R, Jia Z, Ling J, Zuo X, Li M, Gu JG. KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia. Mol Pain. 2015 Jul 31;11:45. doi: 10.1186/s12990-015-0048-8. PubMed PMID: 26227020; PubMed Central PMCID: PMC4521366.

16: Barrese V, Taglialatela M, Greenwood IA, Davidson C. Protective role of Kv7 channels in oxygen and glucose deprivation-induced damage in rat caudate brain slices. J Cereb Blood Flow Metab. 2015 Oct;35(10):1593-600. doi: 10.1038/jcbfm.2015.83. Epub 2015 May 13. PubMed PMID: 25966943; PubMed Central PMCID: PMC4640310.

17: Stott JB, Povstyan OV, Carr G, Barrese V, Greenwood IA. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Proc Natl Acad Sci U S A. 2015 May 19;112(20):6497-502. doi: 10.1073/pnas.1418605112. Epub 2015 May 4. PubMed PMID: 25941381; PubMed Central PMCID: PMC4443360.

18: Mills TA, Greenwood SL, Devlin G, Shweikh Y, Robinson M, Cowley E, Hayward CE, Cottrell EC, Tropea T, Brereton MF, Dalby-Brown W, Wareing M. Activation of KV7 channels stimulates vasodilatation of human placental chorionic plate arteries. Placenta. 2015 Jun;36(6):638-44. doi: 10.1016/j.placenta.2015.03.007. Epub 2015 Mar 21. PubMed PMID: 25862611.

19: Morales-Cano D, Moreno L, Barreira B, Pandolfi R, Chamorro V, Jimenez R, Villamor E, Duarte J, Perez-Vizcaino F, Cogolludo A. Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia. Cardiovasc Res. 2015 Apr 1;106(1):98-108. doi: 10.1093/cvr/cvv020. Epub 2015 Jan 23. PubMed PMID: 25616413.

20: Stott JB, Barrese V, Jepps TA, Leighton EV, Greenwood IA. Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats. Hypertension. 2015 Mar;65(3):676-82. doi: 10.1161/HYPERTENSIONAHA.114.04373. Epub 2014 Dec 29. PubMed PMID: 25547342.

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