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Scopolamine Hydrobromide | CAS#114-49-8 | CAS#51-34-3 | Muscarinic Antagonist | MedKoo-蚂蚁淘商城
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Scopolamine Hydrobromide | CAS#114-49-8 | CAS#51-34-3 | Muscarinic Antagonist | MedKoo

  
  2026-07-31
  
Scopolamine Hydrobromide acts as antimuscarinics like atropine, but may have more central nervous system effects. It is a non-selective muscarinic antagonist. Presently, scopolamine hydrobromide is a widely used clinically to treat motion sickness. Price and Availability

Scopolamine Hydrobromide, purity 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. 114-49-8 (HBr) 55-16-3 (HCl)51-34-3 (free)6533-68-2 (HBr trihydrate) Synonym: Scopolamine Hydrobromide, Scopolamine HBr, (-)-Scopolamine hydrobromide, Scoburen,IUPAC/Chemical Name: 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 3-hydroxy-2-phenylpropanoate hydrobromideInChi Key: WTGQALLALWYDJH-UHFFFAOYSA-NInChi Code: InChI=1S/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1HSMILES Code: CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4.Br Technical Data Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

1: Zhang YL, Li YP. [Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC]. Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3291-4. Chinese. PubMed PMID: 24422394.

2: Xia T, Liu DD, Shi LF, Hu JH. [Pharmacokinetics of scopolamine hydrobromide oral disintegrative microencapsule tablets in Beagle dogs determined with LC-MS/MS]. Yao Xue Xue Bao. 2011 Aug;46(8):951-4. Chinese. PubMed PMID: 22007521.

3: Li FQ, Yan C, Bi J, Lv WL, Ji RR, Chen X, Su JC, Hu JH. A novel spray-dried nanoparticles-in-microparticles system for formulating scopolamine hydrobromideinto orally disintegrating tablets. Int J Nanomedicine. 2011;6:897-904. doi: 10.2147/IJN.S17900. Epub 2011 Apr 28. PubMed PMID: 21720502; PubMed Central PMCID: PMC3124395.

4: Martin-Flores M, Mercure-McKenzie TM, Campoy L, Erb HN, Ludders JW, Gleed RD. Controlled retrospective study of the effects of eyedrops containing phenylephrine hydrochloride and scopolamine hydrobromide on mean arterial blood pressure in anesthetized dogs. Am J Vet Res. 2010 Dec;71(12):1407-12. doi: 10.2460/ajvr.71.12.1407. PubMed PMID: 21117990.

5: Lü WL, Hu JH, Zhu QG, Li FQ. [Preparation of scopolamine hydrobromide nanoparticles-in-microsphere system]. Yao Xue Xue Bao. 2010 Jul;45(7):914-9. Chinese. PubMed PMID: 20931792.

6: Gupta VD Phd. Chemical stability of scopolamine hydrobromide nasal solution. Int J Pharm Compd. 2009 Sep-Oct;11(5):438-9. PubMed PMID: 23966527.

7: Likar R, Rupacher E, Kager H, Molnar M, Pipam W, Sittl R. [Efficacy of glycopyrronium bromide and scopolamine hydrobromide in patients with death rattle: a randomized controlled study]. Wien Klin Wochenschr. 2008;120(21-22):679-83. doi: 10.1007/s00508-008-1094-2. German. PubMed PMID: 19116709.

8: Cao SL, Zhang QZ, Jiang XG. Preparation of ion-activated in situ gel systems of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy. Acta Pharmacol Sin. 2007 Apr;28(4):584-90. PubMed PMID: 17376300.

9: Doty RL, Bagla R, Misra R, Mueller E, Kerr KL. No influence of scopolamine hydrobromide on odor detection performance of rats. Chem Senses. 2003 Nov;28(9):761-5. PubMed PMID: 14654443.

10: Ceyhan T, Kartal M, Altun ML, Tülemis F, Cevheroglu S. LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals. J Pharm Biomed Anal. 2001 Jun;25(3-4):399-406. PubMed PMID: 11377019.

11: Ahmed S, Sileno AP, deMeireles JC, Dua R, Pimplaskar HK, Xia WJ, Marinaro J, Langenback E, Matos FJ, Putcha L, Romeo VD, Behl CR. Effects of pH and dose on nasal absorption of scopolamine hydrobromide in human subjects. Pharm Res. 2000 Aug;17(8):974-7. PubMed PMID: 11028944.

12: Glaser R, Shiftan D, Drouin M. Conformational Pseudopolymorphism and Solid-State CPMAS NMR Studies for Determination of Solvent-Dependent Solution-State Conformational Preferences for (-)-Scopolamine Hydrobromide/Hydrochloride Salts. J Org Chem. 2000 Mar 24;65(6):1898. PubMed PMID: 10814166.

13: National Toxicology Program. NTP Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies). Natl Toxicol Program Tech Rep Ser. 1997 Mar;445:1-277. PubMed PMID: 12594530.

14: Michel A, Drouin M, Glaser R. Solid-state stereochemistry of (-)-scopolamine hydrobromide sesquihydrate, a new polymorph of the anticholinergic drug. J Pharm Sci. 1994 Apr;83(4):508-13. PubMed PMID: 8046605.

15: Statement regarding: Effects of scopolamine hydrobromide on the development of the chick and rabbit embryo. Aust J Biol Sci. 1988;41(4):589-90. PubMed PMID: 3271386.

16: Ogawa N, Haba K, Sora YH, Higashida A, Sato H, Ogawa S. Comparison of the effects of bifemelane hydrochloride and indeloxazine hydrochloride on scopolamine hydrobromide-induced impairment in radial maze performance. Clin Ther. 1988;10(6):704-11. PubMed PMID: 3219685.

17: Markkanen YJ, Laurén L, Peltomäki T. Serum antimuscarinic activity after a single dose of oral scopolamine hydrobromide solution measured by radioreceptor assay. Oral Surg Oral Med Oral Pathol. 1987 May;63(5):534-8. PubMed PMID: 3295650.

18: Markkanen YJ, Pihlajamäki K. Oral scopolamine hydrobromide solution as an antisialagogic agent in dentistry. Oral Surg Oral Med Oral Pathol. 1987 Apr;63(4):417-20. PubMed PMID: 3472139.

19: Yamada S, Noda N, Hayakawa J, Uno K. [Determination of scopolamine hydrobromide in seasick remedies by high performance liquid chromatography]. Yakugaku Zasshi. 1984 Feb;104(2):199-203. Japanese. PubMed PMID: 6737230.

20: Jira T, Pohloudek-Fabini R. [Analysis and stability of atropine sulfate and scopolamine hydrobromide. 3: Studies on the stability of tropane alkaloids; 80: contribution to problems in the use of plastic containers for liquid pharmaceuticals]. Pharmazie. 1983 Aug;38(8):520-3. German. PubMed PMID: 6634922.

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