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Virtual screening of a milk peptide database for the identification of food-derived antimicrobial peptides. - PubMed.cn
2026-08-01
Mol Nutr Food Res 2015 Nov;59 (11): 2243-54.全文索取 Virtual screening of a milk peptide database for the identification of food-derived antimicrobial peptides. Liu Y ,Eichler J ,Pischetsrieder M .
Abstract Milk provides a wide range of bioactive substances, such as antimicrobial peptides and proteins. Our study aimed to identify novel antimicrobial peptides naturally present in milk. The components of an endogenous bovine milk peptide database were virtually screened for charge, amphipathy, and predicted secondary structure. Thus, 23 of 248 screened peptides were identified as candidates for antimicrobial effects. After commercial synthesis, their antimicrobial activities were determined against Escherichia coli NEB5α, E. coli ATCC25922, and Bacillus subtilis ATCC6051. In the tested concentration range (
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